Quifenadine

Chemical name

альфа,альфа-Дифенил-3-��инуклидинметанол (and as hydrochloride)

Gross

C20-H23-N-O

Characteristics

Derived hinoklidina. The white crystalline powder and odourless, gorkovatogo taste. Malorastvorim in water and alcohol.

Of drugs

The drugs-antigistaminnoe, противоаллергическое . Does gistaminove H_1-retseptora. Activates diaminoxydazu-enzyme, inaguiruty histamine, and reduces the mediator in the tissues. Ters spazmogennoe gistamina effect on smooth muscles bronchi and intestines, reduces its gipotenzivny effect and influence on the permeability of the receptacles. Provides antiserotoninovoe moderate, and mestnoanestezirutee holinoliticescoe little effect. Featuring low lipophilicity, poorly crosses the GEB (not to express depressive effect on the central nervous system). The duration of 6-8 h.

Indications

Pollinoz, allergic rhinitis, urticaria, eczema, psoriasis, neirodermit, itchy skin, allergic complications related to the use of drugs or receiving food неинфекционно-аллерг��ческие reaction with bronhospasticski component angioneuroticeski swelling.

Restrictions on the use of

Heavy cardiovascular disease, liver and kidney disease hospital of stomach and duodenal ulcers.

Pregnancy and lactation

In pregnancy (especially in the first trimester) is possible if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Side-Effects

Brown in the mouth cavity, dispeticalkie phenomenon sedative effect.

Precautions

In appointing people whose work requires quick mental or motor response (drivers, etc.) should be pre-determined (by the short-term appointments), there has not been any in the patient after administration hifenadina sedative action.

Dosing and Administration

Inside (after delivery) adults on 0,025-0,05 g 3-4 times per day (maximum daily dose of 0.2 g) for 10-20 days, if necessary again. For children up to 3 years in the 0,005 g 2-3 times a day, from 3 to 7 years in the 0.01g two times a day, from 7 to 12 years in the 0,01-0,015 g 2-3 times a day, over 12 years - to 0,025 g 2-3 times a day. The course of treatment is 10 to 15 days.

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