Treksil

Roman name

Trexyl

The composition and the form of

1 tablet contains terfenadina 60 mg; blistere in 10 pcs. , in box 1, or 10 blisters.

Pharmacokinetics

Well drawn from the blood; Binding protein with the plasma, 97%; Much of becoming active metabolites in the liver. Once inside (60 mg), the maximum concentration in plasma terfenadina achieved after one hour of active metabolites, in a couple of hours The poluraspredelenia 3-4 h, the half-hour from 16 to 23 (average 17 hours). Activity begins in 1-2 hours, reaches a peak in 3-4 hours and lasted for more than 12 hours Distributed to all tissues, stored in the liver and lungs. Report gastrointestinal (60% imposed dose), and news (40%), mostly in the form of metabolites.

Farmakodinamika

Frequency sedative effects (drowsiness, weakness, dizziness, the focus) is similar to the reception and placebo 2 times lower than with traditional admission antigistaminnah drugs.

Indications

Seasonal allergic rhinitis, allergic skin with everything and eritema (urticaria, dermografizm, atopical eczema, contact dermatitis), atopical asthma and asthma caused by the physical stress, acute allergic reaction to drugs, food, insect bites, etc.; Colds disease.

Pregnancy and lactation

We have to take during lactation; In pregnancy is recommended only in cases where the therapeutic effects justify the risk to the fetus.

Contraindications

Гиперчувствительност ь.

Side-Effects

Diarrhoeal disorders, dry mucous membranes mouth, nose, pharynx, cough, pain, sore throat, epistaxis, raising transaminaz, skin reaction (alopecia, angioneuroticeski swelling, photosensitization, rash), ekstrasistolia (in patients with impaired liver).

Patient interaction

No impact on depressive effects of alcohol and benzodiazepines, aggravating corticosteroid and kromoglikata sodium compatible with bronhodilatatormi and H_2-retseptorov antagonists.

Overdosing

The removal nevsosavchegosa drug cardiomonitoring for at least 24 hours (can be arrythmia), symptomatic and supportive therapy.

Storage conditions

The cool and dry, the dark spot

Shelf life

3 years

The registration

011309/01-1999 (Ann.2002)

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