Directory → Intermedianta → Gistaminergicakie funds → Gistaminolitiki → H_2-antigistaminne funds
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The groupN_2-antigistaminne drugs inhibit a parietalnami cells hydrochloric acid, as well as pepsina. Initiation gistaminovykh N_2-retseptorov by stimulation of the digestive, salivary, gastric and pojedudocna glands, as well as jelcheotdelenia. However, in most parietalnae activated cells stomach producyrute hydrochloric acid. This effect is mainly attributable to higher content Zamf (N_2-retseptora stomach involve adenilatziklaza), which increases the activity carboangidraza, participating in the formation of free chlorine ions and hydrogen.
Currently, in the treatment of ulcers stomach and duodenal ulcers are widely used drugs N_2-antigistaminne (zimetidin, ranitidine, famotidin etc.), depressing the secretion of digestive juice (as spontaneous, and stimulirovannuyu gistaminom), as well as reduce the pepsina. In addition, they have influence on the immune processes (as blocking the gistamina) reduces the mediators of inflammation, and allergic reactions from the fat cells and bazofilov. Further development of this group of compounds aimed at finding a more selective about gistaminovykh N_2-retseptorov substances with a minimum of side effects.