Cimetidine

Chemical name

N-Циано-N'-метил-N"-[2-[[(5-м етил-1H-имидазол-4-ил)ме тил]тио]этил]гуанидин (and as hydrochloride)

Gross

C10-H16-N6-S

Of drugs

The drugs-protivoyazvennoe. Does gistaminove H_2-retseptora. If ingestion is rapidly absorbed. As a result of the low lipophilicity not penetrate the central nervous system and has a sedative effect. Suppress spontaneous and stimulirovannuyu gistaminom, pentagastrinom, caffeine jeludocnuu secretion; Little impact on carbaholinovu gipersecretia (no antiholinergicescoy activity). It operates on adrenergicakie receptors is not местноанестезирующег о actions.

Indications

Ulcers disease stomach and duodenal ulcer, gastric giperatidnosti juice (reflux-ezofagit, gastritis, duodenit) syndrome Zollinger-Ellison, pancreatitis, jeludern-kisherne bleeding.

Contraindications

Liver and / or kidney failure, neutropenia, pregnancy, breast-feeding (should abandon breastfeeding), childhood and adolescence (before age 14).

Side-Effects

Headache, dizziness, depression, diarrhoea, worsening excretory functions of the liver, increased liver transaminaz and creatinine in the serum, mialgia, ginekomastia, manifestations antiandrogennogo actions suppression of internal factors lowering intake of vitamin B_12, stoichiometric and thrombocytopenia, allergic reactions (skin irritation).

Patient interaction

Antatsida and metoclopramide reduce suction. Increases in the concentration of serum beta-adrenoblokatorov, anti proximity, eufillina, diazepam (suppresses activity zitohroma P450 and other enzymes liver for detoxification many medicines, which may increase their activity and enhancing side effects of). Increases risk of neutropenia with zitostatikami. Reduces effect androgenov, barbiturates (each), more-metronidazole and m-holinoblokatorov, side-effects of narcotic analgesics. Wrinkles aminazina removals.

Dosing and Administration

Inside, after eating, adult-0.8-1 g / day for 4 reception rate is 4-8 weeks supporting therapy for the 0.4 g per night for a few months; Abolition therapies were gradually. B / b-to 0.2 g in 4-6 hours, drip - 0.2 g for 2 h, the maximum speed Infusion 0.15 g / h, perhaps development of heart rhythm and hypotension.

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