Famotidine

Chemical name

3-[[[2-[(Аминоиминометил) амино]-4-тиазолил]мети��]тио]-N-(аминосульфони��)пропанимидамид

Gross

C8-H15-N7-O2-S3

Characteristics

White or daffodil crystalline powder. It is soluble in acetic acid poorly in the methanol and water, virtually nerastvorim in ethanol.

Of drugs

The drugs-protivoyazvennoe. Does gistaminove H_2-retseptora, ingibiruet basal and stimulirovannuyu secretion of hydrochloric acid; Suppresses activity Pepsina.iz intestine absorbed incomplete material is 40-45% more under the influence of food and decreases in the application antatsidov. Linking blood plasma is 15-20%. C_max achieved after 1-3 hours 30-35% metabolized in the liver to education S-oksida and presented by kidney clubockova filtering and kanalzeva secreta. 25-30% dose of the inside, and 65-70% imposed on / in the detected in the urine in an unmodified form. T_1/2 - 2.5-3 hours In patients with severe renal insufficiency (Cl creatinine below 10 ml / min), it goes up to 20 h (to be correct dose). Once inside the begins in one hour is the maximum for 3 h and lasts 10 to 12 hours In a / with the greatest impact is in 30 min. Single dose (10 and 20 mg) suppresses the secretion of 10-12 hours

Indications

Ulcers disease stomach and duodenal ulcers (the treatment and prevention of exacerbations), symptomatic ulcers, erosive ezofagit, reflux-ezofagit, syndrome Zollinger-Ellison, the bleeding of the upper digestive tract divisions (in / in), prevention erosivno-yazvennah alleged losses in the face of the reception NPVS aspiration and gastric contents during general anesthesia.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (at the end of treatment).

Side-Effects

Brown mouth, loss of appetite, nausea, vomiting, discomfort abdominalny, raising transaminaz in the serum, holetsatical jaundice, fatigue increased, the noise in the ears, headache, hallucinations rarely, fever, adults, muscle pain, arthralgia, dry skin, allergic reactions : angioneuroticeski swelling, itching, urticaria, conjunctivitis, bronhospazm; Irritation at the injection.

Precautions

Patients with human kidney function (Cl creatinine below 30 ml / min), the daily dose reduction to 20 mg. Solution for injection prepared immediately before use. Children appoint preparation does not Recomenduetsa.pri therapy ulcers stomach and duodenal ulcers should be removed from the patient of malignant tumours (bioptata study of the ulcer). To use caution in case of the liver.

Dosing and Administration

Inside. In acute ulcers stomach and duodenal ulcers 40 mg per night or 20 mg twice per day (morning and evening), the length of the course from 4 to 8 weeks; With the aim of preventing attacks on the 20 mg once a day at night for six months. In reflux-ezofagite-20 mg 1-2 times per day for 6-12 weeks, SARS Zollinger-Ellison 20-40 mg four times per day (if necessary dose of the drug increases) .V / in (struino or drip). The average dose of 12 mg every 12 hours The syndrome Zollinger-Ellison : initial dose of 12 mg every six hours, then adjust the dose; For the prevention of gastric aspiration of the contents of anaesthetic : 20 mg per day of operation or at least two hours in advance.

Directory → Intermedianta → Gistaminergicakie funds → Gistaminolitiki → H_2-antigistaminne funds → Famotidine