Kwamatel

Roman name

Quamatel

Pharmacokinetics

Once inside C_max achieved within 1-3 h of 0,07-0,1 mg / J Bioavailability of 40-45%. T_1/2 of plasma-2,3-3,5 p, and Cl creatinine less than 10 ml / min T_1/2 be increased to 20 hours Passes through the placenta and is the breast milk. After receiving the drug inside, unedited, with the urine output 30-35%, and the in / in-a 65-70% preparation.

Farmakodinamika

Decreases basal stimulirovannuyu and secretion of gastric juice content of the hydrochloric acid and pepsina. Activity begins in one hour and continues for 10 to 12 hours Following in / with a maximum of moving for 30 minutes. No impact on the fermentnuu zitohroma P450 in the liver and speed metabolism at the same time the drugs which biotransformiroyutza with zitohroma P450.

Indications

Ulcers disease duodenal ulcers and stomach cancer (acute phase, relapse prevention); Symptomatic ulcers; Reflux-ezofagit; Prevent aspiration gastric juice in the general anesthesia (Mendelssohn syndrome); Syndrome Zollinger-Ellison.dla more tablets : functional neuralgia associated with increased secretion of stomach; Erosive Ezofagit.dl in / with the introduction of more : bleeding from the upper gastrointestinal divisions (the Integrated Management).

Contraindications

Hypersensitivity to famotidinu and other blokatoram gistaminovykh H_2-retseptorov, pregnancy, lactation, children's age (for the on / introductions).

Side-Effects

Brown mouth, nausea, vomiting, flatulence, constipation, diarrhea, and the appetite, increase in liver enzymes, headache, dizziness, noise in the winter, increased fatigue, drowsiness, temporary personality disorders, fever, irregular, muscle pain, pain in joints, alopecia, ordinary acne, dry skin, itching, bronhospazm, and other manifestations gipersencibilization. Very rarely agranulozitos, pancitopenia, lakopenia, B19.

Patient interaction

The pH of the stomach contents, while employment may decline by stripping ketokonazola. If Kwamatela antatsidnami with drugs, the break between their admission must be at least 1-2 hours

Precautions

Before therapy blokatorami gistaminovykh H_2-retseptorov needed gistologicescoe study bioptata from ulcers to exclude malignant disease. It should be treated with caution and in reduced doses appoint drug patients with the human liver.

Storage conditions

List B. The temperature 15-25 ° C

Shelf life

3 years

The registration

012002/02-2001

The drug forms

Tablets 20 mg : 4.2.2 pills pink, with a film covering a diameter of about 8 mm labeled <F20> one Storone.tabletki 40 mg : 4.2.2 pills pink, with a film covering a diameter of about 8 mm labeled <F40> on the same side.

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