Nizatidine

Chemical name

N-[2-[[[2-[(Диметиламино)м��тил]-4-тиазолил]метил]��ио]этил]-N'-метил-2-нитр о-1,1-этендиамин

Gross

C12-H21-N5-O2-S2

Of drugs

The drugs-protivoyazvennoe. Does gistaminove H_2-retseptora. It stops and the basal stimulirovannuyu (food, caffeine, betazolom, pentagastrinom, gistaminom, azetilholinom) products parietalnami cells Kislota.pri salt ingestion quickly and adequately absorbed. Bioavailability is about 70%. C_max achieved through sunbathing and In sossoudistom with circulates in part (35%) in the blood (mostly alfa-1-kislam glikoproteinom) form. Penetrates into tissue and organs : stomach, kidneys, livers, pancreases, etc. T_1/2 is 1-2 hours Most of the stands with urine unchanged to about 60%, less than 6% is the faeces. The kidney removal directly depends on the size of clubockova filtering and kanalzeva secreta.

Indications

Ulcers disease stomach and duodenal ulcers (the treatment and prevention of exacerbations), reflux-ezofagit, pancreatitis (or acute exacerbation of chronic), bleeding from the upper gastrointestinal divisions.

Contraindications

Hypersensitivity, pregnancy, breast-feeding (at the end of treatment), children's age.

Side-Effects

Violation of liver function (increased in the blood of transaminaz, alkaline phosphatase), drowsiness, sputannosti consciousness, tachycardia, or aetiology, anaemia, ginekomastia, thrombocytopenia, sweating, urticaria, rash.

Patient interaction

While large doses of aspirin increases the salicylic acid in the blood. Antatsida reduce suction.

Overdosing

Symptoms : slezotechenie heightened slunootdelenie, vomiting, diarrhoea, Mioz.lechenie : reception activated carbon induction vomiting or lavage, symptomatic therapy.

Precautions

Daily dose should not exceed 480 mg. For patients with impaired renal dosing regime should be tailored to the Cl creatinine. Before treatment to rule out a malignant disease in the stomach.

Dosing and Administration

Inside, in / in (throw 300 mg in 150 ml of solution compatible to the / introductions). With Peptic Ulcer cancer in the phase of deterioration and sound stomach ulcer inside is 150 mg twice a day or 300 mg once a day, in the evening; For the prevention of acute-150 mg once a day, Vecerom.v / in a 10 mg / h or bolusno, without breeding-100 mg (4 ml) three times a day.

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