Ranitidine

Chemical name

N-[2-[[[5-[(Диметиламино)м��тил]-2-фуранил]метил]т��о]этил]-N'-метил-2-нитро -1,1-этендиамин (as hydrochloride)

Gross

C13-H22-N4-O3-S

Characteristics

White daffodil or granular powder bitter taste with the smell of sulphur. Gigroskopichen, sensitive to light. Easily soluble in water, a moderate in alcohol, low in chloroform, pH 1% target solution weathering.

Of drugs

The drugs-protivoyazvennoe. Selectively blocking gistaminove H_2-retseptora. Suppress basal and stimulirovannuyu secretion of hydrochloric acid, reduces the acidity and gastric juice. The duration of the dose 150 mg inside 12 C.bystro absorbed in the digestive tract : C_max is 550 ng / ml of plasma and is two hours; Bioavailability about 50% of the dose effect of a "through the liver. Associated with the plasma protein by 15%. Penetrates gistogematicalkie through barriers, including through placental, but poorly-by GEB. Partly biotransformiroetsa in the liver to N-oksida (main metabolite, 4% dose), and S-oksida demetiliruetsa. T_1/2 at normal creatinine Cl - 2-3 h, and reduced (20-30 ml / min), 8-9 pm The urine within 24 hours unchanged to return about 30% of oral and 70% in / in the dose imposed. A significant concentration in the milk. Speed and the elimination little dependent on the state of the liver and is mainly concerned with the function of the kidneys.

Indications

Ulcers disease stomach and duodenal ulcers (treatment and prevention), Npvs-gastropatia, chronic ulcers, reflux-ezofagit, syndrome Zollinger-Ellison, chronic neuralgia with epigastralnami zagrudinnami and pains; Preventing stress ulcers, recurrent bleeding, Mendelssohn syndrome.

Contraindications

Hypersensitivity, cirrhosis with portosystemic encephalopathy in history, the liver and kidneys, pregnancy, breast-feeding (at the end of treatment), children's age (up to 14 years).

Side-Effects

Headache, dizziness, drowsiness, vertigo, anxiety, arousal, depression, hallucinations (mostly in the seriously ill and the elderly), obratimaya vagueness of view, automatic movement detectors (tachycardia, aetiology, asistolia, AV blockade arrythmia), constipation, diarrhea, nausea, vomiting, pains in the abdomen, pancreatitis, gepatozellliarnae, holetsaticalkie or mixed hepatitis with jaundice or not, arthralgia and mialgii, increased creatinine in the blood, lakopenia, granulozitopenia, thrombocytopenia, agranulozitos, pancitopenia, gipoplasia bone marrow and aplastic anemia, immune haemolytic anaemia, ginekomastia, impotence, reduced libido, alopecia, rash, multiformnaya erythema, swelling angioneuroticeski, anaphylaxis.

Patient interaction

Antatsida and sukralfat may reduce removals. Changes intake and excretion of other drugs (according to their kislotno-osnownami properties).

Overdosing

Treatment : induction vomiting or stomach wash, and convulsions - diazepam in / in and bradikardii - atropine in jeludockovh aritmiah - lidocaine.

Precautions

To use caution in patients with impaired renal with porphyria (in history) and the children. Before treatment should rule out a malignant neoplasms in the stomach and gastrointestinal bleeding. Patients who are older human liver or kidney disorder may (sputannosti) consciousness, requiring lower doses. Bystrorastvorimae tablets contain sodium, which should be taken into account when appointing people who have shown that it is confined to the reception, and aspartame, bad for patients with phenylketonuria.

Dosing and Administration

Inside, every day, 150 mg twice a day or 300 mg at night. In erozivne ezofagite-150 mg four times daily, the maximum permissible dose for adults-6 g / Sut.detam appointed on the inside of 2-4 mg / kg twice a day for a stomach ulcer and duodenal ulcer (maximum 300 mg / day), with reflux-ezofagite - 2-8 mg / kg 3 times a day. V / m, / in the 50 mg every 6 to 8 hours

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