Roksan

Roman name

Roxane #

The composition and the form of

1 tablet prolonged release coated liner contains roksatidina 75, or 150 mg; in the stripe 10 pcs. , in a cardboard box 10 strips.

Of drugs

Protivoyazvennoe, antatsidne. Does gistaminove H_2-retseptora mucous membrane stomach suppresses production of hydrochloric acid obkladocnami cells.

Pharmacokinetics

Rapidly metabolized in the liver with the formation of the active deazetil-roksatidina. Linking blood plasma is 6-7%. T_1/2 is about 5 hours Two thirds of the active substance and metabolites derived from the kidneys. The small portion excreted milk disorders.

Clinical pharmacology

The evening reception 75 mg or 150 mg morning secretia gastric juice suppressed by 88% or nearly 100%, respectively; Secretia days, by 35% and 44%, respectively.

Indications

Ulcers disease stomach and duodenal ulcers (the treatment and prevention of exacerbations), symptomatic gastric ulcers, erosive and ezofagit reflux-ezofagit.

Pregnancy and lactation

Application during pregnancy is possible only by the most stringent conditions. The appointment breastfeeding should stop breast-feeding (out with breast milk).

Contraindications

Hypersensitivity, anuria.

Side-Effects

Siegenia or diarrhoea, flatulence, nausea, vomiting, increased tranzithornoe transaminaz level in the serum, headache, and allergic reactions immunopatologicakie (skin rashes, itching, mialgii, arthralgia); In some cases, dizziness, intermittent sleep, anxiety, drowsiness, and impaired vision, lakopenia; Very rarely change heart rate, lower libido.

Patient interaction

Changes lost more drugs in blood, weakening (eg ketokonazol) or increasing (eg midazolam) their effect.

Overdosing

The excessive use standard arrangements for the disposal neabsorbirovannogo preparation.

Precautions

The appointment should be deleted malignizatiou stomach ulcer. Not recommended for use by children, patients with acute violations of the liver.

Dosing and Administration

The inside is not liquid, squeezed of water. The duration of individual. To treat ulcers stomach and duodenal ulcers, 75 mg morning and evening, or 150 mg evening (on average within 4 weeks); For the prevention of attacks ulcers-75 mg evening. For patients with impaired renal dosing regime established on the basis of Cl creatinine : 20-50 ml / min-75 mg once a day (evening), less than 20 ml / min, 75 mg every 2 days (evening); prophylactically-75 mg every two days, Cl creatinine 20-50 ml / min or 75 mg twice weekly evening (Cl with less than 20 ml / min).

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