Roxatidine

Chemical name

2-Гидрокси-N-[3-[3-(1-пипер идинилметил)фенокси]п ропил]ацетамид (and in the form of acetate or acetate hydrochloride)

Gross

C17-H26-N2-O3

Of drugs

The drugs-protivoyazvennoe. Does gistaminove H_2-retseptora, suppressing the production of hydrochloric acid obkladocnami stomach cells. The evening reception 75 or 150 mg morning secretia actually 88% and 100%, daily, by 35% and 44% соответственно.Быстр�� and almost completely absorbed from the digestive tract, eating no effect on the speed and completeness of suction. The blood of a small (6-7%) binds to proteins. Easily passes through gistogematicalkie barriers. Two-thirds of dezazetiliruetsa esterazami (liver, intestine thin, blood serum), and becomes an active metabolite, 1 / 3 biotransformiroetsa to inactive products; T_1/2, 5-6 hrs in health and increased proportionally reduced kidney function with their diseases, as some 70% roksatidina excreted mochevforodaschimi ways; to a small extent (0.22% dose) enters the breast milk.

Indications

Ulcers disease stomach and duodenal ulcers, symptomatic gastric ulcers, erosive ezofagit, reflux-ezofagit.

Contraindications

Hypersensitivity, the liver and kidneys, anuria, pregnancy, breast-feeding (for the period of treatment should stop), child.

Side-Effects

Headache, dizziness, weakness, drowsiness, intermittent sleep, anxiety, depression, paresthesia, impaired vision, thrombocytopenia, lakopenia, neutropenia, diarrhoea disorders, constipation, diarrhoea, flatulence, nausea, vomiting, tranzithornoe raising transaminaz blood mialgii, arthralgia, changes in heart rate, giperprolaktinemia, ginekomastia, galactorea, impotence, transient decrease in libido, skin rashes, itching of the skin.

Patient interaction

Wrinkles biotransformatia xenobiotics (blockade zitohroma P450). Changes degree and the speed of absorption and excretion in the urine of drugs (according to their characteristics kislotno-osnownami).

Precautions

Before treatment to rule out a malignant tumors in the digestive tract.

Dosing and Administration

Inside, squeezed of water, 75 mg morning and evening, or 150 mg per night; For the prevention of complications and recurrence-75 mg per night. In violation of the kidney dose determine, in accordance with the values Cl creatinine : in the range of 20 to 50 ml / min, 75 mg at night, less than 20 ml / min, 75 mg at night, through the day, prophylactically, 75 mg twice a week at night. Duration of treatment is two weeks, during which no ulcer rubtsuyutza should continue therapy still two weeks

Directory → Intermedianta → Gistaminergicakie funds → Gistaminolitiki → H_2-antigistaminne funds → Roxatidine