Ulkosan

Roman name

Ulcosan

The composition and the form of

1 tablet contains ranitidine hydrochloride 150 mg; in the package 30 pcs.

Of drugs

Protivoyazvennoe, antigistaminnoe. Does H_2-retseptora gistamina.

Pharmacokinetics

It absorbed characterized effect "of a" through the liver. Bioavailability is about 65%. C_max plasma achieved after 1-3 hours at 400-500 ng / ml after administration of 150 mg, the therapeutic plasma is about 12 hours Linking blood plasma low (15%), heavily metabolized in the liver (approximately 70% imposed dose). T_1/2 - 2-3 pm Report mostly kidneys (up to 30% in an unmodified form).

Farmakodinamika

Decreases basal and stimulirovannuyu (gistaminom, gastrinom and azetilholinom), the secretion of hydrochloric acid, increases the pH of gastric juice by reducing activity pepsina could reduce skin reactions to the allergens.

Indications

Ulcers disease stomach and duodenal ulcers (treatment and prevention), "stress" ulcers, reflux-ezofagit, syndrome Zollinger-Ellison.

Pregnancy and lactation

Contraindicated during lactation. During pregnancy appoint strict condition for a short time.

Contraindications

Гиперчувствительност ь.

Side-Effects

Headaches, dizziness, weakness, drowsiness, nausea, pain in the abdomen, constipation or diarrhoea, increased plasma levels of AST, ALT, glutamataminotransferzy, creatinine, rarely lakopenia, thrombocytopenia, allergic reactions (skin rash).

Patient interaction

Antatsida and sukralfat reduce removals holinoblokatora increase bioavailability. Pirenzepin magnifies the effect. Prolong down metoprolola (twice), reduces kidney Cl triamterena and procainamide. Increases the glipizida, nifedipina, fenitoina, cyclosporine, theofillina, disulfiram, tests, oral contraceptives. Changes (increases or decreases) the effect of diazepam.

Precautions

Be wary appoint people with disabilities kidney and liver (in these cases the dosage should be reduced).

Dosing and Administration

Inside, 1 tab. morning and evening or 2 table. evening before rubtsevania ulcer (without life of at least four weeks). To prevent the recurrence of ulcers on one table. evening for 12 months. The syndrome Zollinger-Ellison-6 table. (in exceptional cases or more) a day. Patients with Cl creatinine below 50 ml / min appoint one table. (150 mg) once a day.

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