Cromoglicic acid

Chemical name

5,5'-[(2-Гидрокси-1,3-пропа ндиил)бис(окси)]бис[4-о��со-4H-1-бензопиран- 2-carbonova acid (and in the form of disodium salt)

Gross

C23-H16-O11

Of drugs

Drugs, the cell, противоаллергическое . 4-3 membranes sensitised fat cells, inhibits entry of calcium ions, and degranulatia release of gistamina, bradikinina, lakotrienov (including slow responsive substance arginine), prostaglandines, and other biologically active substances. Warn of allergic and inflammatory reactions, bronchospasm, which ingibiruet chemotaxis Eosinophils. It has the ability to block receptors specific mediators of inflammation. Prolonged use reduces the frequency of attacks of asthma and facilitates the flow, reduced need for Bronchiodialator drugs and glukokortikoidah. In patients with mastocitozom through 2-6 weeks from the beginning of treatment there has been a reduction in the symptoms of the digestive tract (diarrhea, abdominalnaya pain, nausea, vomiting), and skin (hyperemia, urticaria, skin), which is 2-3 weeks after its abolition. Redukcija symptoms in allergic eye disease manifests itself in a period of a few days to several weeks. When 8-14 allergicescom rinite effect manifests itself in a period of 1 week and reaches its maximum after 1-4 Ned.dlitiona studies in mice, homakah, rabbits and rats have identified cancer and tertogennogo action. In a Injecting mice, rats and krolikam in doses up to 338 times the therapeutic dose for a person who has no effect on fertility. In higher doses toxic to the female body, increases the frequency resorption fruit and reduces their estate Tela.posle intake of absorbed no more than 1% (0.45% return with urine for 24 h), the remainder from faeces. The instillation in the eye poorly absorbed in the blood system (0.03%), sledove quantities (less than 0.01%) infiltrating watery fluid and the total withdrawal within 1 day. Following intranasal use of less than 7% absorbed by the system in the bloodstream. In inhalation impose up to 90% preparation captured by trahee and large bronchitis. The light absorbed by 5-15% dose (C_max in the blood is 15 to 20 minutes), a small portion is in the stomach, the rest of steaming. Suction with mucous membranes decreases with increase in the number secret. Linking blood plasma proteins, 65-75%. Do not metabolised and out of the body the same as the number of urine and jelchew 24 hours T_1/2 is 1-1.5 hours In small quantities enters breast milk. Effects of a single dose until 5 p.m.

Indications

Capsule : food allergy (with a proven antigen), as an aid : Baby Ulcerative Colitis, proktit, koloproktit, Mastocitoz.glaznae drops : conjunctivitis (acute and chronic allergic, spring), and keratit keratokongunguit, symptoms of dry eye, hypertension and eye fatigue, eye irritation due to food allergies (environmental factors, occupational hazards, the household chemistry, cosmetics, ophthalmic dosage forms, plants and pets). Nazalny sprays : round and seasonal allergic rhinitis, �оллиноз.Ингаляционны е forms : bronchial asthma, including atopica, physical effort and astmatical triad, chronic bronchitis with bronhoobstruktive syndrome.

Restrictions on the use of

The polyps in the nose cavity (for intranazalnah Forms)

Pregnancy and lactation

Contraindicated (especially in the first trimester of pregnancy). At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to benzalconia gidrohloridu), pregnancy, breast-feeding, child up to 2 years (measured spray up to 5 years).

Side-Effects

The inhalation of : From the Skin : exantema, dermatitis; Rarely urticaria; In some cases, swelling Stroke, fotodermatit, exfoliativei Dermatit.so the nervous system and sensory organs : in some cases, malaise, dizziness, irritability, insomnia, hallucinations, tremor, peripheral neuritis, noise Ushah.so part of the intestine : nausea, gastroenteritis; in some cases, bad taste in his mouth, stomatitis, glossit, swelling slunna parotid gland, ezofagospazm, neuralgia, aches, pain in the abdomen, diarrhoea, constipation, a violation of Pecheni.so the urogenital system : frequent urination, Nefropatia.so the respiratory system : irritation of the bronchial inhalation (cough, craving for vomiting, transient causes; rarely expressed with the drop in external device, which requires the preparation), pharyngitis; very rarely krovoharkanye, laryngeal edema, eosinophilic Pnevmonia.so the circulatory system : in some cases, the pain in the chest, periarterialny vasculit, heart failure, pericardit, gipotenzia violation of a heart Ritma.so the musculoskeletal system : myofasciitis, in some cases, muscle and the joint pain, polimiozit, swelling Sustavov.prochie : rarely savorotocnaya Bolezn.pri ingestion : Since part of the intestine : nausea, vomiting, feeling abdominal discomfort, Diarea.prochie : skin rashes, pain in Sustawah.pri intra : Since part of the intestine : bad taste in the mouth, swelling Asicia.so the respiratory system : short-term irritation of mucous membrane and the increased secretion from the nose; very rarely, bleeding from the nose, pitting mucous membrane nasal cavity, cough, Udusie.prochie : headache, artralgia, an anaphylactic reaction (cough, the glotania, skin itch, oedema, or lips century, breathing difficulty), exantema, Krapiwnica.dla eye drops-term pain and impaired vision, hyperemia close-slezotechenie, swelling close-sense foreign body in the eye, dry eye, barley.

Specific guidance

It is designed for short-acute attack of asthma and asthma status. The patient must be advised of the need for regular use of medication. Ingalatia solution should be performed with a compressing, or ultrasonic wave through ingalatora front mask or Mouthpiece. The aerosol container to use to stir during inhalation keep upright (dosing valve must be located at the bottom). Ingalirovnie contents of the capsules are made with a special pocket turboingalatora (Spinhaler "), which put the capsule with a product. Click on the top ingalatora, punctured capsule, and with the active effort dahatelnom patient inhaling the powder is inhaled.

Patient interaction

Beta-adrainomimetiki, glukokortikoida, antihistamines means and theofillin potenziruut effect. Should ingalirovti bromgexin, ambroksal mixed with the solution kromoglicieva acid.

Precautions

Be wary appoint patients with a human liver and kidney. Treatment continued until the allergogenny factor. Lifting drug should be gradually decreasing doses over a period of 1 week. Cough, which occurs following inhalation can be pain reception glass of water. If the use of drugs is a recurring bronhospazm, it is recommended that a preliminary inhalation bronhorasshirath funds. In related therapy bronhodilatatormi their use of ingalaciei kromoglicieva acid. When the eye drops benzalconia chloride (preservative) did not wear soft contact lenses during treatment. Rigid lenses are encouraged to take 15 minutes prior to instillation. It should be borne in mind that, after putting in the eye is the short-term (and should not do the work requiring greater attention).

Dosing and Administration

Inside, adults and children (over 12 years) to 2 caps. (200 mg) four times a day for half an hour before meals and sleep. Children from 2 to 12 years - 1 caps. (100 mg) 4 times a day (up to 40 mg / kg / day). Drops eye : kongungualno, adults and children, to 1-2 drops 4% solution of 4-6 (8) times a day at regular intervals (with the effect of the interval between the application gradually lengthened). Intranasal 1 aerosol dose in each bow the 3-4 times a day. Inhalation : with bronchial asthma, adults and children over the age of 5 years (dose aerosol) at the beginning of treatment, the dose of 1-2 4-6 (8) times a day. To prevent asthma physical effort directly to the physical work is a further admission medication. In severe cases, the two doses of 6-8 times a day, with clinical improvement on the one dose four times a day.

Directory → Intermedianta → Gistaminergicakie funds → Gistaminolitiki → Stabilisers membranes fat cells → Cromoglicic acid