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Intal

See also Cromoglicic acid

Roman name

Intal

The composition and the form of

one dose of aerosol inhalations of sodium kromoglikata 1 or 5 mg; cartridges in the 200 or 112 doses respectively, in a carton st.1 1 ml for inhalations kromoglikata contains sodium 10 mg; 182,000,000 in 2 ml, in a cardboard box 48 pcs.

Pharmacokinetics

After inhalation aerosol measured about 10% of dose absorbed from respiratory tract system in the bloodstream. After inhalation solution respiratory secretions absorbed 8% rate, the remainder of the removed from the lungs to shocks expiratory air or deposited on the walls of rotoglotki, then proglatavetsa and presented by the digestive tract. Of blood in the system Blood drawn 1% imposed doses. Reversible binds to plasma proteins (about 65%) is not metabolized. Report from the body unchanged to the urine and jelchew approximately equal numbers.

Indications

Bronchial asthma (including asthma physical effort) in children and adults (prevention and treatment).

Pregnancy and lactation

Assign with caution.

Contraindications

Гиперчувствительност ь.

Side-Effects

In applying intala sometimes cough and short bronhospazm (narrowing of the bronchi clearance), cough calm reception glass of water immediately after inhalation, and in the case of repeated bronchospasm make pre ingalatia bronhorasshiratego facility (see Izadrin, Jortziprenalina sulfate, 215).

Patient interaction

It should not be combined with neselektivei бета-адреноблокатора��и.

Precautions

The patient must be briefed on the need for regular admission Intala unlike the occasional admission of drugs used to reduce bronchoconstriction. Solution ingalirovti be mixed with bromgexinom and amboroxol.

Storage conditions

List B. In the dark place at a temperature of no higher than 30 ° C. Do not store in the refrigerator.

Shelf life

4

The registration

006,056 (Ann.2000, BRP)

Of drugs

Intal is a specific tool to be used in bronchial asthma and bronhospasticeskih conditions (steady narrowing clearance bronchi). At the heart of it is based on the ability to delay the release of fat cells mucous membrane respiratory tract mediator substances for the promotion of bronchospasm, allergies and inflammation (bradikinina, slowly responsive substance, gistamina etc.). It may be that the drug is also partly to the embargo receptors specific mediators of inflammation, as well as holino- and adrenomediatorov limfoidnykh cells. The intala evident in the local application of inhalations. The ingestion effect is not.

Indications for use

Intal effective in patients with bronchial asthma, and provides warning of the application to the development of asthma and bronchial asthma. Continuing the long urejaet preparation and facilitates attacks of asthma, reduces the need for means bronhorasshirath and korticosteroidah. For edema (withdrawal) acute asthma medication applied. Intal most effective in patients are relatively young and have not yet developed chronic changes in the lungs. Effects of the drug was in the form of atonicescoy asthma, but the effect can also be observed in инфекционно-аллергич��ской of the disease, with astmaticescom bronchitis, pnevmosklerose with attacks suffocation, particularly if allergic component.

Dosing and Administration

Dose spray for nebulizers. Adults (including the elderly) and children shall primary dose inhalation 2 four times a day. In achieving optimal therapeutic effect may shift to supporting dose : 1 breathing four times a day. Dose products can be increased up to 2 inhalations 6-8 times a day when a heavy course of the disease. Additional admission preparation can be done directly to the physical load to prevent attack of asthma. Powder for nebulizers. Ingalirovnie contents of the capsules are made with Spinhaler (special ingalatora) Activated breathing effort on the patient inhaling. Intal effective when swallowed capsules. The product dispensed with its immediate entry into the respiratory tract. Adults (including the elderly) and children product appoint one capsule four times a day : 1 capsule at night, one in the morning and 2 in the interim, with an interval of 3-6 hours. The need to increase the dosage to 6-8 capsules per day may arise where a heavy course of the disease. Additional reception drug can be made directly to the physical load, or other effects that may provoke severe asthma. In achieving sustained therapeutic effect may shift to a minimum dose of support to ensure adequate monitoring of disease. Mortar for nebulizers. Solution should ingalirovti through compression, or ultrasonic wave through ingalatora front mask or Mouthpiece. Adults (including the elderly) and children appoint one ampoule four times a day with the help of ingalatora. In more severe cases, the reception frequency can be increased to 5-6 times a day. In related therapy bronhodilatatormi (means facilitating clearance bronchi), it must be taken before ingalaciei intala. In patients receiving therapy korticosteroidami (hormone-crust napochechnikov or their synthetic analogues), appendix intala can reduce the dose of support or refuse to admit corticosteroid drugs. During reduce corticosteroid dose of the patient should be kept under close supervision of a doctor; Rate lower dose should not exceed 10% in the week. Increasing doses of corticosteroid may be necessary to improve symptoms, related infections, expressed antigennom impact or stress. If it had been possible to reduce dose corticosteroid, intal be taken until resumed hormone therapy. If necessary, the admission intala lifting products are gradually for a week. During lowering doses could recur symptoms.

Form of

Capsule to 0.02 g (20 mg) in the package of 30 capsules. Applied only to inhalations by special turboingalatora. The ingestion of the capsules do not. Dose aerosol inhalations for 200 doses (1 dose-0.001g). Dose aerosol inhalations for 112 doses (1 dose-0,005 grams). Mortar for nebulizers sealed in 2 ml (1 ml - 0.01g) in the package of 48 pieces.

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