Ketotifen

Chemical name

4,9-Дигидро-4-(1-метил-4-п��перидилиден)-10Н-бензо [4,5]циклогепта[1,2 b] tiofen-10-on (and in the form of fumarata)

Gross

C19-H19-N-O-S

Of drugs

Drugs, the cell, protiwallergicescoe, antigistaminnoe, противоастматическое . It stops the release of gistamina etc. mediators (slow reacting substance arginine, limfokin, etc.) from the fat cells and bazofilov. Nekonkurentno H_1-gistaminove blocks receptors ingibiruet fosfodiesterzu increases Zamf level in the cells. Suppress sensitization Eosinophils recombinant zitokinami rights and their accumulation in the respiratory passages. Prevents development hyperreactivity symptoms of the respiratory tract caused by a factor activate platelets or by allergens. Warn of bronchospasm (no bronhorasshiratego action). Clinical effects developed through 6-8 weeks. Oppressing Zns.posle intake of rats almost entirely. Bioavailability of approximately 50%, due to the effects of the "first walk" through the liver. Time to C_max plasma-p 2-4, tying with the plasma protein-75%. Passes through GEB and enters breast milk. Metabolised in the liver; Chief metabolite (кетотифен-N-глюкурони д) virtually inactive. Withdrawal from the body through two phases : the T_1/2 3-5 h and 21 h respectively. Within 48 hours with urine output bulk of the dose : 1%, unedited, and 60-70% in the form of metabolites.

Indications

Preventing attacks of asthma (all forms), allergic bronchitis, pollinoza; Prevention and treatment of allergic rinita, allergic conjunctivitis, Urticaria (acute, chronic), atopic dermatitis, migraines.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding, child up to 3 years (tablets) or 6 months (syrup).

Side-Effects

From the nervous system and sensory organs : sedative effects decrease reactivity, block, a sense of fatigue, mild dizziness, headache, drowsiness, and rarely concern, sleeping, nervousness (especially for children). For part of the intestine : dry mouth, increased appetite, nausea, vomiting, gastralgia, Zapor.prochie : B19, anesthetic, increased body mass index, allergic skin reactions.

Patient interaction

Do sedative effects, pills, etc. antigistaminnah and ethanol. Oral antidiabetics drugs increase the risk of developing trombozitopenia.

Overdosing

Symptoms : drowsiness, and eye, sputannosti consciousness, disorientation, or bradi- tachycardia, gipotenzia, dyspnoea, zianoz; Convulsions, anxiety (particularly children); Evolution Koma.lechenie : induction vomiting, stomach wash, the appointment of activated carbon plant laxatives; Symptomatic therapy : maintaining vital functions, in initiating and convulsions, a short acting barbiturates and benzodiazepines. Dialysis ineffective.

Precautions

It is designed to attack heavily asthma. Not recommended immediately revoke previous therapy beta-adrainomimetikami, glukokortikoidami, ACTG (lifting out for a minimum of two weeks, gradually reducing the dose). Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention. When expressed sedativom action in the first two weeks appoint 0.5 mg twice a day. Treatment out gradually, over a period of two to four weeks (possible relapse asthma symptoms). In patients while receiving oral gipoglikemicakie, should control the number of platelets in the peripheral blood. It should be borne in mind that the syrup contains ethyl alcohol (2.35 vol%), and carbohydrates (0.6 g / ml).

Dosing and Administration

Inside, at the time of delivery, adults and children older than 3 years old the first 3-4 days, and 1 mg evening (possible sedative effect), then 2 mg / day (1 mg morning and evening). If necessary, in adults and children 10 years and older, the daily dose increased to 4 mg (2 mg twice a day). Syrup : children between the ages of 6 months to 3 years in one dose of 2.5 mL (0.05 mg / kg) twice a day; Children aged 3 years to 5 ml (1 tsp) in the first 3-4 days once the evening, and then two times (morning and evening).

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