Nedocromil sodium

Chemical name

9-Этил-6,9-дигидро-4,6-дио ксо-10-пропил-4Н-пирано[ 3,2-g]хинолин-2,8-дикарбо��овой dinatrieva acid salt

Gross

C19-H15-N-Na2-O7

Characteristics

Yellow powder, soluble in water.

Of drugs

The drugs - противоастматическое . Lock release from the various cells (eozinofila, mast cells neitrofila, macrofagi, monocita and platelets) mediators of inflammation, including gistamina, Cytokines, lakotrien S_4, PGD_2, hemotaksicskih factors, enzymes (beta-glukuronidaza etc.). After inhalation captured on the walls Bronchus tree and inhibits the development of the early and late stages of astmaticescoy reaction caused by the inhalation serum. Decreases highly permeable receptacles provides local противовоспалительно е effect on the mucous membrane of the bronchi. Affects the MUP nerves in the lungs, suppressing the akson-reflex and contributes to the release of sensory cortex (substance P, A neirotoksin etc.). Continuous longstanding use reduces giperreaguosti respiratory tract infection by nonspecific bronhaakonstrictora improves the external device reduces the intensity and frequency of attacks suffocation and severity of cough. Effective in light and moderate forms of asthma. Improves night symptoms and reduces the need for a full bronhodilatiruth drugs. With the 30 minutes before the impact of a chemical irritant, serum or physical load prevents astmaticescoy acute reaction and suppresses its later phase, observed in 6-12 h after provocation. Therapeutic effect of moving by the end of the first week, the maximum improvement in clinical status and lung function is usually over a period of two to four weeks after the start of Lechenia.v experimental studies have been found carcinogenic and mutagennogo actions, the impact on fertility, or tertogenna embriotoksicski activity (to a small extent passes through the placenta). System bioavailability aerosol negligible : with a single dose of 3.5-4 mg, it is 7-9%, with multiple ingalciah 17%. Drawn mainly from the respiratory tract (5-6%), absorption from the gastrointestinal ingestion spray-2-8%. Average C_max healthy volunteers (1.6 ng / ml) is achieved after 28 minutes after application. In patients with bronchial asthma C_max-2.8 ng / ml recorded between 5-90 min. Linking plasma protein reaches 89% (with concentration in plasma 0.5-50 µ g / ml). T_1/2 - 1,5-3,3 hours Do not metabolised in unaltered within 12 hours with urine excreted 3.4% rate, of which about 75% of output in the first six hours Twenty renal excretion (with the single and multiple designation) is 5%. In small quantities enters breast milk experimental animals.

Indications

Bronchoobstructive syndrome : bronchial asthma, including physical exertion, bronhospasticskie reaction inducyruemye cold air, inhalants allergenami, atmospheric pollution, etc., obstruguy chronic bronchitis.

Restrictions on the use of

Pregnancy (I term), and breast-feeding.

Pregnancy and lactation

Be wary designate of pregnancy (especially in the first trimester), and breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to ftoruglerodam), a children's age (up to 12 years).

Side-Effects

From the respiratory system : coughing, tightening in the chest, difficulty in breathing, causes Bronhov.so the nervous system : dizziness, headache Bol.so part of the intestine : pain in the abdomen (5%), unpleasant tastes after inhalation, nausea, vomiting, Dispepcia.prochie : arthritis, or stoichiometric lakopenia seen rising body temperature, pain, sore throat, or across the body, outwardly and other signs of infection.

Patient interaction

Do (mutually) effect of stimulants beta-adrainoretseptorov, Corticosteroids, derivatives metilksantina, ipratropia bromide.

Precautions

Aerosol is not designed for short-acute bronchospasm.

Dosing and Administration

Inhalation. Adults and children over 12 years of the initial dose-2 inhalation (4 mg) 4 times daily, if necessary, and 6-8 times a day, for maintenance therapy for two inhalations twice a day; Additional admission may directly to the physical strain on the prevention of asthma physical effort.

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