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Parlazin

See also Cetirizine

Roman name

Parlazin

Characteristics

Antigistaminnoe means of a group of piperazine derivatives, the main metabolite carbauxilirovanny gidroxizina.

Pharmacokinetics

Once inside absorbed quickly and completely, simultaneous eating to have an insignificant effect on skin. Linking protein is 93%. The apparent mass of distribution-0,5-0,8 l / kg There is intense metabolizmu in the liver. One of the metabolites formed in okislitionom O-dealkilirovania side chain has no antigistaminna activity. T_1/2 the compound is 7,4-9 hours Children final T_1/2 is 6.2 hours (33% shorter than that of adults). In children under the age of 4 years T_1/2 4.9 hours T_1/2 the elderly as well as in patients with chronic liver disease increased by 50% compared with the levels in a healthy adult population. T_1/2 cetirizina can grow in renal failure : in patients with mild and moderate malnutrition kidney function reaches 19 to 21 hours compared with 7.4 hours in patients with normal renal function. Kidney klirens normal activities kidney is about 40 ml / min in light kidney failure-7 ml / min, and at a moderate 1.5 ml / min. Although the clinical significance of these facts is not found in such patients should be correct dose preparata.60% cetirizina dose of 10 mg is with urine unchanged to 24 hours, 10% displayed at the four-day period; With the spread is 10% for the five days. O-alkilirovanny metabolite found in plasma and faeces, but not in the urine, which include the withdrawal of Jelchew.pronicaet in CNS to a minimum and does not interact with the central N_1-gistaminovmi receptor. Penetrates into breast milk. In gemodialise farmakokinetika cetirizina does not change.

Farmakodinamika

The presence of polar groups attached to a side chain mixture reduces lipophilic and, as a consequence, the ability to penetrate the central nervous system (respectively decreasing severity sedative effect), increasing selectivity towards N_1-gistaminovm receptors, as well as reducing the side effects caused by holinoblokiruta активностью.Цетиризи�� is also having an impact on the cell inflammation, oppressing migration Eosinophils or ingibiruya factors hemotaksisa Eosinophils. Cetirizin greatly reduces Eosinophils accumulation in the skin, as well as allowing the skin reaction histamine estimated size blister and giperemia. In addition, he was oppressing and other inflammatory cells infiltrata, for example нейтрофилы.Предупреж��ает development and facilitates the allergic reactions has protivozudnam and protivoekssoudative action. Decreases blood capillaries, prevents tissue swelling, relieve suffering smooth Musculatura.actie begins in 20 minutes. The maximum effect is a one hour, the duration of the 24-hour

Indications

Seasonal and year-round allergic rhinitis and conjunctivitis, allergic zudaschie Medicine, pollinoz (senna fever), urticaria (including chronic idiopathic), Kwinke swelling.

Pregnancy and lactation

Pregnant women do not mean that (the well-controlled research on human subjects is not available; Experimental studies show that cetirizin has teratogenic effects). Contraindicated during lactation, as cetirizin enters breast milk and the risk of side effects that are breastfed infants exceeds the possible benefit to the mother.

Contraindications

Гиперчувствительност ь to cetirizin or other components of the drug, pregnancy, lactation period, the age of children up to 6 years (tablets), children up to 1 year (drops reception inside).

Patient interaction

There is interaction with the following products : glipizid, diazepam, zimetidin, azithromycin, pseudoephedrine, ketokonazol, erythromycin. Joint appointment with theofillinom (400 mg / day) resulted in a 16% decrease in the overall ground cetirizina (kinetics theofillina unchanged).

Precautions

Be wary appointed in chronic renal failure moderate and severe symptoms (requires a correction mode), as well as patients older (to be a correction mode). Children under 1 year cetirizin not appointed in any form, as in this age group, the safety and efficacy of the drug is not установлены.Парлазин�� tablets may be nominated in children 6 years of age and older. Treatment of children aged 1 to 6 years that the Parlazin ® drops reception Vnutri.v case of the reaction гиперчувствительност и cetirizinom treatment immediately Prekrashchaut.u patients with renal insufficiency due to the slow ascent substances preparation may koumoulirovati. In appointing cetirizina these patients in normal recommended adult dose can be observed side effects associated with holinoblokirutm act and the impact on the central nervous system. These patients dose cetirizina Sniziti.u that older patients, there is a higher sensitivity to holinoblokirutm side effects (eg dry mouth, urine retention), if such symptoms are for the mentally ill, or not growing, treatment Parlazinom ® should be discontinued. Holinoblokirtee expressed or psychological influence on the central nervous system in the appointment Parlazina ® in normal doses, as a rule, does not arise. Nevertheless, the risk of accumulating cetirizina increases (due to a progressive decline in renal function in elderly patients). Patients suffering from lactose intolerance, it is necessary to warn that Parlazin ® pills contain Lactozu.tak as is the case with other antihistamines means treatment Parlazinom ® should be discontinued 3 days before the Prik-testov (to prevent distortion reaction). During treatment should refrain from the use of alcohol Napitkov.pri first admission Parlazina ® patients should pay attention to the possibility of side effects (such as itching), which can affect the ability to drive or mechanical devices. Patients are encouraged to refrain from performing such work by the disappearance of side effects. In the future, when driving vehicles and the work requiring greater attention, patients should not exceed the recommended dose of 10 mg per day.

Dosing and Administration

Inside, the tablets in combination with large amounts of water (200 ml), drops prior to grow Vode.vesroslae and adolescents over 12 years of age : standard dose of 10 mg (1 tab. Or 20 drops) once a day, preferably at Noci.deti aged 6-12 years : usual dose, 5 mg (1 / 2 table. , or 10 drops) twice a day (morning and evening), or 10 mg (1 a tablet or 20 drops) Vecerom.deti aged 2-6 years : the normal daily dose of 5 mg (10 drops) per day; You can divide the dose by 2 receiving 2.5 mg (5 drops) morning and Vecerom.pojilam sick recommended dose reduced to 5 mg in Deny.ballam with renal insufficiency appoint half the recommended dose (5 mg / day).

Storage conditions

In the dark place at a temperature of no higher than 25 ° C

Shelf life

2 years. Open a bottle store up to four weeks

The registration

015607/02

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