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Prostaglandins, tromboksana, lakotriena and their antagonists
The groupProstaglandins, biologically active substances occurring in the cells of arahidonova and some other unsaturated fatty acids (digomolinolenova) in fosfolipidah membranes. Depending on how biotransformation enzyme arahidonova acid can be formed not only NG (including prostaziklin and tromboksana when participation of the sintetaz), but also lakotriena (oxidation products on the 5-lipooksigenaznomu).
In particular chemical structure NG divided into groups with Latin indices A, B, E, F, etc. and the group numbered in Arabic numerals (PGE_1, PGE_2 etc.), according to the number of double bonds in the molecule.
Prostaglandins and their synthetic analogues are multiple physiological (drugs) activity. They believe hormone substances ( "local" league), the regulatory cell metabolism.
An example of this is the impact of emissions on Oxytocics activity smooth muscles, secretion, blood (including microcirculation), as well as other body functions. Prostaglandins groups F_2alfa E_2 and have a strong stimulating effect on miometri and their applications in medical practice as a uterotoniziruth Funds for the weakness of Labor (see Uterotoniki). Prostatziklin (PGI_2) is a very powerful endogenous inhibitor of aggregation and adhesion of platelets has vazodilatiruta and hypertensive activity. Instead, tromboksan to aggregation and limit receptacles.
Lakotriena play an important role in the development of inflammation and bronchoconstriction; Their antagonists would have important applications for cupping the bronchial asthma allergic and inflammatory syndromes.