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Xalatan

See also Latanoprost

Roman name

Xalatan

Characteristics

Analogous NG F_2-alfa (with molecular weight 432.58).

Pharmacokinetics

Increases uweoscleeralny outflow watery moisture not have a significant influence on its products. As an inactive predecessor (latanoprost is a isopropyl ether) are permeates through rogovitsu, gidrolizuacy to bioactive latanoprosta acid. C_max in watery moisture is approximately two hours after application. The eye tissues active form little metabolized; Metabolism occurs mainly in the liver. T_1/2-17 min. two major metabolita no activity triggered mainly via the urine.

Farmakodinamika

The increase uweosclairlland outflow Reduce the watery moisture in the interior environments eyes and reduces inner pressure. The effect begins in 3-4 h after the introduction, is a maximum 12 hours and lasts for at least 24 hours Has no effect on products watery moisture permeability гематоофтальмическог о barrier.

Indications

Otkratougolnaya glaucoma, high ofthalmotonus.

Pregnancy and lactation

The drug does not increase the frequency of birth defects. When pregnancy apply in the event that the potential benefits exceed the potential risk to the mother and fetus and the newborn child. Nursing mothers appointed with caution (active form and metabolites could infiltrate the mother's milk).

Contraindications

Hypersensitivity; Children age (safety and efficacy have not been established).

Side-Effects

Light feeling foreign body in the eye, hyperemia kongyunctiv (small or moderate), tranzitorne point epiteliale erosion makuliarny swelling (often in patients with afakiei or psevdofakiei from hrustalikom in the front chamber eyes); increased pigmentation radugki (due to stimulation of melanin melanozitami radugki) and the change in its colour primarily in patients with the mixed (blue, zeleno-, sulfur or jelto-coricneva) radugki colour, and very rarely in patients with evenly coloured eyes (blue, gray, green, brown), all iris or part become more intense color; geterohromia constant (for the treatment of an eye), skin rash.

Patient interaction

Reducing vnutriglaznogo increasing pressure to combine with бета-адреноблокатора��и (timolol), adrenomimetikami (dipivalil adrenalin), besides carboangidraza (acetazolamide); holinomimetikami with weaker. Farmatsevticeski incompatible with tiomersalom (pretipitation).

Precautions

Before treatment should inform the patient of a possible change eye color. During treatment requires mandatory regular surveys pigmentation radugki because color changes develop slowly and may remain undetected for several months; in an intensive skin treatment ceased.

Dosing and Administration

Kongungualno, buried in kongungualny bag on one drop once a day, in the evening; To release a dose on a normal (that is, 1 drop). With more frequent imposition of the Snijaetsa.pri a combination therapies eye drops drugs entering at intervals of not less than 5 minutes.

Storage conditions

List B. In the dark place at a temperature of 2-8 ° C. After the autopsy, so that the temperature does not exceed 25 ° C for 4 weeks.

Shelf life

3 years

The registration

012867/01

The drug forms

Transparent colourless solution.

All products of this group