Latanoprost

Chemical name

Изопропил-(Z)-7[(1R,2R,3R,5S)3, 5-дигидрокси-2-[(3R)-3-гид��окси-5-фенилпентил]ци��лопентил]-5-гептеноат

Gross

C25-H40-O5

Characteristics

Analogous Pgf_2alfa. Square or slightly yellowish oil. Well soluble in acetonitrile, acetone, etilazette, isopropanol, methanol and oktanole, unreduced almost in the water.

Of drugs

The drugs-protivoglaucomnoe. Is selective agonist F_2alfa prostaglandinovykh receptors. Lowers inner pressure by increasing the outflow of fluid vnutriglazna through vascular sheath eyeball patterns. Has no effect on products watery moisture. Could not resize missed. The instillation well permeates through rogovitsu eyes in the form of an inactive predecessor (isopropyl ether) hydrolyses and biologically active acid, which is determined during the first 4 h in vnutriglazna liquid and the first hour-plasma. The distribution of 0.16 l / kg The maximum concentration in the aqueous moisture is the 2 h after application. Distributed initially in the front segment eyelids and centuries, and then trickles into the rear segment. The eye tissues active form little metabolized; Biotransformation occurs mainly in the liver. T_1/2 (after the / in the local and software) is 17 min. two major inactive metabolita running mostly in the urine.

Indications

Otkratougolnaya glaucoma, high ofthalmotonus.

Restrictions on the use of

Children's age (safety and efficacy of the children are not identified).

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь.

Side-Effects

Feelings foreign body in the eye, hyperemia close-point epiteliale erosion makuliarny swelling (often with afakii or psevdoafakii from hrustalikom in the front chamber eyes), increased pigmentation iris changing its colour primarily in patients with the mixed (blue, zeleno-, sulfur or jelto-coricneva) colour iris and rarely, if even its colour (blue, gray, green, brown) : whole rainbow shell or part become more intense color; geterohromia constant (for the treatment of an eye), forming an eye slits, skin rashes.

Patient interaction

Beta-adrenoblokatora (timolol), adrenomimetiki (via dipivalil) inhibitors carboangidraza (acetazolamide), holinomimetiki (weaker) heighten the effect. Farmatsevticeski incompatible with tiomersalom (pretipitation possible).

Overdosing

Symptoms : eye irritation, hyperemia or kongyunctiv Episcleera.lechenie : symptomatic.

Precautions

Prior to the anticipated therapy patient must be informed of a possible change of colour of eyes. During treatment to the regular survey pigmentation iris because staining develops slowly and may remain undetected for several months. In the case of interchange pigmentation therapy ceased.

Dosing and Administration

Instillatin mainly evening to 1 drop in the patient eye on one occasion; In the case of pass-dose impose a normal (that is, 1 drop). When coupled with a adrenomimetikami, besides carboangidraza, beta-adrenoblokatorami, holinomimetikami instilliruut drop of at least 5 minutes.

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