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Prepidil

See also Dinoprostone

Roman name

Prepidil

The composition and the form of

Gel for the endozerwickalnogo-3 g (2.5 ml) dinoproston 0.5 Sciences also kolloidnyi dvuoksid silicon; Triazetinv disposable syringes plastic to 3 grams, together with the catheter sterile; In the paper cartons 21.90.

Pharmacokinetics

After endozerwickalnogo the gel C_max achieved through 30-45 minutes, and then rapidly decreased.

Indications

The cervix to leave.

Contraindications

Hypersensitivity, the anamnesticeskih information about kesarevom section extensive surgical interventions in utero, difficult and / or traumatic childbirth, 6, and more mature pregnancies, lack of pelvis mother and the head of the fruit anomaly fruit prior to the fruit distress, opening amniocentesis bladder, a krovanistye during pregnancy from the genital tract unspecified etiology, infection lower divisions sexual tract.

Side-Effects

Aberrant reduction uterus, vomiting and / or diarrhoea, changing choose fruit, the fruit distress, reduced newborn status (estimated at Apgar below 7).

Specific guidance

Avoid the gel in ekstraamnioticescoe Space (possible giperstimulyatsia uterus).

Patient interaction

Do tokotroponuu oxytocin activity.

Precautions

Use only in a hospital environment. Prior to the appointment Prepidila need to evaluate the size of the fruit and the pelvis. Be sure to monitor the uterine activity of the cervix and fruit. With a history PNDS or tetaniceskih Tuesday reductions kidney or liver pathology (accompanied by metabolic disorders), a continuous monitoring of uterine activity and the status of the foetus and closely monitored. The caution used in patients with asthma or increased vnutriglaznam pressure (glaucoma).

Dosing and Administration

The contents of a syringe (3 g gel with 0.5 mg dinoproston) with the accompanying catheter give cervical canal (below the domestic zev). The procedure requires 10-15 minutes on the back, to minimize the outflow Gel.esli desired result from the use of Prepidila is recommended interval prior to the appointment / in oxytocin is 6-12 hours If the answer to the initial dose Prepidila not achieved can assign it again. Recommended repeat dose 0.5 mg, and the interval from the previous introduction to 6 p.m. Additional supplies and the interval should be a doctor, based on the clinical situation. The maximum recommended dosage for hour period, 1.5 mg.

Storage conditions

List B. The temperature 2-8 ° C

Shelf life

2

The registration

008740

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