Cyproheptadine

Chemical name

4-(5H-Дибензо[a,d]циклоге��тен-5-илиден)-1-метилпи перидин (as hydrochloride)

Gross

C21-H21-N

Characteristics

White or slightly yellow crystalline powder, soluble in water and chloroform, easily soluble in methanol, sparingly soluble in ethanol and virtually nerastvorim broadcast.

Of drugs

The drugs-antigistaminnoe, protiwallergicescoe, antiserotoninovoe. Does gistaminove H_1-retseptora. Reduces bodily reactions histamine, prevents and facilitates the allergic reactions. Decreases blood capillaries, prevents pulmonary tissue. Duration of up to eight hours Has expressed antiserotoninovoe effect. Ters spazmogennoe of serotonin in the smooth muscle (receptacles intestine, etc.). Efficiency in the zudath dermatozah, easing headache and migraine, increased appetite and antidiareynoe effect in patients with tumors kartsinoidnami antigistaminnam to act and oppression serotoninova transfer. Provides weak holinoliticescoe and sedative effect. Decreases gipersecretia somatotropina in akromegalia and release the ACTG syndrome Itsenko-kushinga.v experimental studies have been identified and mutagennogo tertogennogo effect impact on Fertilnosti.pri ingestion quickly and completely (more than 90%) absorbed from the digestive tract. C_max achieved in the first two hours, the therapeutic plasma is 4-6 hours Evenly distributed in the body, enters the central nervous system. Intensive metabolised (gidrauxilirovnie followed glukuronidirovaniem) in the liver. After a single dose of 4 mg (in the form of tablets or syrup) 2-20% excreted gastrointestinal (of which 34% in unaltered), and not less than 40% presented with urine mainly in the form of kongugatov glukuronova with acid. In reconsidering daily use in doses from 12 to 20 mg (as syrup) style form drug in the urine is not found. When kidney failure off slower.

Indications

Urticaria (acute, chronic and cold), pollinoz, savorotocnaya disease round or seasonal allergic rhinitis, allergic conjunctivitis, swelling angioneuroticeski; Allergic reaction to the admission of drugs, blood transfusions, the bite of insects, a rentgencontrastnykh substances; Skin diseases, zudaschie Medicine, contact dermatitis, toxicodermia, neirodermit, eczema; Headache vascular origin, migraine, vazomotornyi rhinitis; Anorexia, cachexia (during recuperation, and chronic diseases), a disease Kushinga (mono or combination therapy), a comprehensive therapy �остгастрорезекционн��го syndrome increased motor function in the intestine kartsinoide, chronic pancreatitis, asthma and anaphylacticakih reactions.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, narrow-angle glaucoma, clean giperplazia prostate cancer, a delay urination, narrowing in the digestive tract of which stenoses privratnika, stenozirutaya peptical ulcers, predisposition to otekam, CNS disorders in older patients, pregnancy, breast-feeding, breast age (up to 6 months).

Side-Effects

From the nervous system and sensory organs : weakness, sedative effect, reducing emotional reactions, anxiety, anger, arousal, headache, dizziness, drowsiness, ataxy, visual Galloucination.prochie : nausea, dry mouth, increased body mass index, skin rashes.

Patient interaction

Deprimiruty effect ciprogeptadina reduce caffeine and fenamin reinforce (each), sleep and sedation, alcohol. Tricyclic antidepressants potenziruut holinoliticaskie effects and psychological impact on the central nervous system. Increases effect of opioid analgesics.

Overdosing

Symptoms : children - midriaz and stiffness pupils, hyperemia skin, hyperthermia and stir, anxiety, hallucinations, ataxy, atetoz, convulsions, collapse, coma; Adults - block, depression, coma, then agitation, convulsions; Rarely hyperthermia and hyperemia skin Pokrovov.lechenie : induction vomiting, the appointment of activated charcoal inside, and then washing the stomach; in the development of life-threatening symptoms of the central nervous system or expressed atropinopodobnykh effects, a solution fizostigmina salicilata; shown sossoudossoujiwate-and anti-convulsants, IVL. Psihostimulatora and analepticalkie protivopokazana means.

Precautions

The first reception that night, after eating (sedative effect). Be wary designate children and elderly patients (possible Hypersensitivity), patients with bronchial asthma, thyrotoxicosis, vnutriglaznam high pressure, hypertension and other cardiovascular diseases. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention, especially in the beginning, individually determined, the period of treatment. During the course of treatment not use alcohol.

Dosing and Administration

Inside the food. Adults - 4 mg three times daily; For the treatment of chronic Urticaria-2 mg three times a day; Acute migraines amok - 4 mg once, in the absence of the effect in 30 minutes, 4 mg; For the maintenance therapy to 4 mg three times daily; with anorexia-12 mg three reception; maximum daily dose of 32 mg. The duration of treatment with the objective of increasing body mass index should not exceed six months. Children 6 months to 2 years (with caution only in special cases) to 0.4 mg / kg / day for 3-4 weeks, 2-6 years, 6 mg / day, 6-14 years, 12 mg / day, with anorexia to 8 mg / day in 3 admission. The treatment of anorexia and cachexia not more than 3 months. The maximum daily dose for children 2-6 years, 8 mg, 6 and 14 to 16 mg.

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