Dihalroergotamine

Chemical name

(5'альфа,10альфа)-9,10-Диг��дро-12'-гидрокси-2'-мети л-5'-(фенилметил)эргота ман-3',6',18-трион (as nelfinavir)

Gross

C33-H37-N5-O5

Characteristics

Refers to a group gidrirovannah derived alkaloids LPV. Colorless transparent solution.

Of drugs

The drugs-sossoudorasshiratee, protivomigrenoznoe. Does 5-HT_1D serotoninove receptors blocks and alfa_1- альфа_2-адренорецепто��ы receptacles. Is vazokonstrictorom intracranial pressure and has expressed neiroingibitoriani properties. Decreases photographic and fonofobiu. Several increases tone veins. In inhalation introduction (nazalny spray) is rapidly absorbed, it should prove to be a highly effective (mild migrenozna attack in 20-30 min), and the return of the body (lower risk of unwanted effects). The ingestion (pills) reduced bioavailability. After the / m the effect is manifested through 15-30 minutes, and continued for 3-4 hours

Indications

Артериогипотонически й of a headache, migraine, vazospastical stenocardia, ortostatical hypotension.

Contraindications

Hypersensitivity expressed arteriosclerosis, organic heart failure, myocardial infarction, arterial hypertension, human peripheral blood circulation, sepsis, shock, as the kidneys, I trimester of pregnancy, breast-feeding (at the time of treatment is required abandonment of breastfeeding).

Side-Effects

Nausea, vomiting, diarrhoea, difficulty nasal breathing disruptions (rare), dizziness, swelling, skin itch.

Patient interaction

Effect increase antihistamines, sedatives and narcotic drugs. The combined application with the others. Antimigrenoznami Programme (ergotamine, sumatriptan) increases the likelihood of acute pressure. Do certain antigipertenziveh funds. Macrolides increase digidroergotamina concentration in the blood.

Overdosing

With the high degree of sensitivity to ergotaminovm drugs may be symptoms ergotizma - zagrudinne pain, respiratory depression, muscle weakness, pain and parestesia in limbs accompanied by cianosis and weakening pulsation in the peripheral blood, expressed ischemic changes his hand and foot (rare), vomiting, diarrhoea, deliri, convulsions, coma Sostojanie.lechenie : Temporary removal of the drug, Local sogrewate wraps, a vazodilatatorov (sodium nitroprusside, fentolamin), special care to prevent tissue damage.

Precautions

During treatment is not recommended smoking (there is a greater risk of peripheral spazmirovania receptacles).

Dosing and Administration

Inside, in / m, c / GMT For heavily migrenoznogo attack usual dose for adults 5-20 drops of 0.2% solution, or one table. retard (2.5 mg) either / m or m / to 0.25 ml of 0.1% solution 1-2 times a day (subject to the repeated every hour for 3 p), or similar nazalny 1 dose into each nostril (maximum of four doses in the attack).

Directory → Intermedianta → Serotoninergicakie funds → Dihalroergotamine