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NaramigSee also NaratriptanRoman nameNaramigThe composition and the form ofMale Film-coated-1 tabl.narathriptana hydrochloride 2.5 megawatts blistere 2, 4 or 6 pcs. ; In a box one blister.PharmacokineticsRapidly absorbed from the digestive tract. C_max achieved in 2-3 hours at after taking 2.5 mg of about 8.3 ng / ml for women and 5.4 ng / ml for men. Bioavailability was 74% for women and 63% for men. Volume of 170 litres. Linking blood plasma low (29%). Passes gistogematicalkie barriers, including GEB determined tissues. T_1/2 on average 6 hours Average after Cl in / in a 470-ml / min for men and 380 ml / min for women. Kidney Cl same for men and women (220 ml / min). Report mostly in the urine and 50% of dose in an unmodified form, 30% of active metabolites.IndicationsMigraine with the agency and without it (mild asthma).ContraindicationsГиперчувствительност ь (incl. to sulfanilamidam), myocardial infarction, ischemic heart disease, diseases of the peripheral vessels, stroke, the cerebral circulation, uncontrolled arterial hypertension expressed by the liver and kidneys, gemiplegical, baziliarnaya or ofthalmoplegical form migraines, the simultaneous appointment etc. 5-ht_1-retseptorov agonists; elderly (over 65 years) and the child or youth (under 18), age, pregnancy, breastfeeding (must stop).Side-EffectsThe pain, tingling sensation, heat, gravity, or sdavljenia contraction, nausea, vomiting.Patient interactionIncompatible with drugs containing ergotamine and its derivatives.Storage conditionsList B. The temperature is not above 30 ° CShelf life3 yearsThe registration015862/01 |
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