Naratriptan

Chemical name

N-Метил-3-(1-метил-4-пипе��идинил)-1Н-индол-5-этан сульфонамид (in the form of monogidrohlorida)

Gross

C17-H25-N3-O2-S

Of drugs

The drugs-protivomigrenoznoe. Vsokoseleguo institute 5-HT_1B/1D serotoninove receptors. Big extended during migraine attack vnutricerepnae receptacles way down neiromediatorov and vazoaktiveh cells from the tip troinicnogo nerve (blockade 5-HT_1D-рецепторов).Быстр о absorbed in the digestive tract. Bioavailability-63% of men and 74% among women. Time to C_max (5.4 ng / ml for men and 8.3 ng / ml in women after receiving 2.5 mg) 2-3 hours Volume of 170 litres. Linking plasma protein does not exceed 30%. Penetrates the GEB. In the liver, with the participation of zitohroma P450 is inactive metabolites. T_1/2 averages six hours Cl after in / in a 470-ml / min for men and 380 ml / min for women. Write mainly with urine in an unmodified form (about 50%) and in the form of metabolites. Cl reduced by 50% at a moderate kidney failure and 30% if there is a violation of the functions of the liver. Kidney Cl-220 ml / Min.bystro (one hour) and effectively eliminates migrenoznae stroke. Complete disappearance of pain in the early 6700 indicated that 60-65% of patients. Effective in menstrual migraines. Effect dozozawisim, including for migraines related nausea, and fono- fotofobia, the best results were in the employment of 2.5 mg.

Indications

Migraine fascination with and without aurora (mild asthma), migrenozny status (as part of an integrated treatment).

Contraindications

Hypersensitivity, incl. to sulfanilamidam, gemiplegical baziliarnaya or ofthalmoplegical form of migraine, ischemic heart disease, myocardial infarction, the cerebral circulation, diseases of the peripheral vessels (syndrome peremejateisa hromota), uncontrolled blood pressure, pregnancy, youth (under 18), and old age.

Side-Effects

Parestesia, dizziness, drowsiness, weakness, pain, or sdavljenia compression throat and the neck, suffering coronary, human peripheral blood circulation, nausea, vomiting.

Patient interaction

Do effect sedatives. Erqotamin etc. protivomigrenoznae drugs increases the likelihood of adverse events.

Precautions

In patients with renal and hepatic insufficiency daily dose should not exceed 2.5 mg. Not recommended to appoint Cl creatinine less than 15 ml / min and used to prevent migraines (with the exception of menstruation). It should not be used within 24 hours after the other triptanov or ergotamine and similar drugs. During the period of treatment to refrain from the road and work with potentially dangerous machinery requiring greater attention and speed of reaction.

Dosing and Administration

Inside during the attack, one 2.5 mg. Upon returning to the symptoms of migraines, are not less than 4 hours The maximum daily dose of 5 mg. To prevent menstrual migraines-2.5 mg once a day for a few days during or prior to the onset of menstruation.

Literature

1. Puhalskaya TG, Kolosov OA, Osipova VV, Wayne A. New perspectives in the treatment of migraines / / Mountain. pharmacology and pharmacotherapy-1997 .- T. 6.2. J. Goadsby Serotonin 5-HT1B/1D receptor agonists in migraine : comparative pharmacology and its therapeutic implications / / CNS Drugs - 1998 .- V. 10 .- P. 271-286.3. Klassen A., Elkind A., M. Asgharnejad et al. Naratriptan is effective and well tolerated in the acute treatment of migraine. Results of a double-blind, placebo, parallel-group study. Naratriptan S2WA3001 Study Group / / Headache .- 1997 .- V. 37-N-10 P. 640-645.

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