Zolmitriptan

Chemical name

(4S)-4-[[3-[2-(Диметиламино) этил]-1H-индол-5-ил]мети��]-2-оксазолидинон

Gross

C16-H21-N3-O2

Of drugs

The drugs-protivomigrenoznoe. Yes institute 5-HT_1B/1D serotoninove receptors have moderate affinity to 5-HT_1A receptors. It vazokonstricciu, oppressing release cortex (vazoaguogo intestinalnogo peptide, substance P, etc.). It absorbed in the intestine, C_max achieved within 1 h. Material is a little over 40% (effect of a "through the liver). Linking blood plasma approximately 25%. T_1/2 - 2.5-3 hours The liver is biotransformation intensive education N-десметил-производно��о (in the 2-6 times more active than the original substance), and a number of inactive metabolites. Report the news is in the form of metabolites, some 30% from faeces in an unmodified виде.Приостанавливае�� development migraine attack without direct pain relief. Apart from the short-attack pain weakens nausea, vomiting (especially when Bush left), photo and fonofobiu. The starting 15 to 20 minutes and reaches a peak within 1 h. Greater effects observed in the employment of altitude attack. Vsokoeffectiven in complex treatment migrenoznogo status (a series of several heavy, the next one after other attacks migraines for 2-5 days). Alleviate menstrualnuu migraines. High doses have sedative effect and cause drowsiness.

Indications

Migraine (mild attack).

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, severe arterial hypertension, ischemic heart disease, Wpw-sindrom human heart rhythm, heavy human liver, child and aged (over 65) age.

Side-Effects

Nausea, dry mouth, dizziness, drowsiness, a sense of heat, fatigue, a sense of gravity and sdavljenia throat, neck, legs and chest, the tranzithornoe AD mialgia, muscle weakness, paresthesia.

Patient interaction

Moklobemid increases in the tissues. Is combination with other protivomigrenoznami Programme (ergotamine, digidroergotamin, paracetamol, etc.).

Overdosing

Symptoms : sedative Effect.lechenie : symptomatic therapy, including the road respiratory tract, monitoring and maintenance functions of the cardiovascular system.

Precautions

Prior to the start of treatment to a detailed neurological examination for the exclusion of organic disease of central nervous system, as well as assessment of the cardiovascular system. Not recommended reception at the same time as other drugs from the group agonists 5-HT_1D receptors and use for the prevention of migraine attacks. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Dosing and Administration

Inside, 2.5 mg. If there is no effect or retidivirovanii pain again in 2 hours The maximum single dose of 5 mg maximum daily dose is 15 mg.

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