Metandienone

Chemical name

(17 бета)-17-Гидрокси-17-мет��ландроста-1,4-диен-3-он

Gross

C20-H28-O2

Characteristics

White or white with a yellow-brown crystalline powder. Very little is soluble in water. Easily soluble in alcohol.

Of drugs

The drugs-anabolicescoe, gemopoeticescoe. Anaboliceski steroid. Entered into the cell nucleus and activates genetic apparatus cells, which leads to an increase in the synthesis of DNA, RNA and structural proteins, enzymes activate chain woven respiration and more moist air, oxidizing fosfaurilirovania, ATP synthesis and accumulation makroergov inside the box. Does anabolic and suppresses katabolicescie processes caused by glukokortikoidami. Can increase muscle mass and reduce fat deposits and negative azotistomu balance. Gemopoeticescoe effect of the increased synthesis of Erythropoietin. The anti due to the increased concentration of S_1 factions complement inhibitor and the decline of S_2 and S_4 complement fractions. Androgennaya activity (moderate) may contribute to the development of secondary sexual characteristics of a male. Quickly and completely absorbed in the stomach, small bioavailability due to the effect of a "through the liver. The blood with specific globulinami vectors associated 90%. Treated final biotransformation in the liver with the formation of active metabolites. Excreted kidneys. The duration of up to 14 hours

Indications

Human Protein Metabolism, cachexia, in the debilitating disease, anaemia, angioneuroticeski swelling, the growth Turner syndrome.

Restrictions on the use of

Pregnancy, breast feeding, old age.

Contraindications

Hypersensitivity, swelling breast, renal and hepatic failure, heart failure, myocardial infarction, ischemic heart disease, diabetes, prostate adenoma cancer, gipercalziemia.

Side-Effects

Diarrhoeal phenomenon : nausea, vomiting, diarrhoea, pain in the abdomen; Gepatozellliarnaya carcinoma, obturazionnaya jaundice, gipokoagulyatine of the tendency to bleeding, depression, insomnia, muscle stiffness, and adenoma adenocarqingoma prostate cancer, type breast ginekomastia men and symptoms virilization in women poliuria increases urination, swelling, leukaemia, allergic reactions.

Patient interaction

Do the anti, and antiagregantov gipoglikemicakih funds, as well as side effects gepatotoksicnah drugs.

Dosing and Administration

Inside, the food. Adults, 5 mg 1-2 times a day. The highest dose of 50 mg / sut. Children : up to two years, 0.05-0.1 mg / kg; 2-5 years, 1-2 mg, between 6 and 14 years of age, 3-5 mg in 1-2 reception. Course to 4 weeks. Again course-by 6-8 weeks.

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