Nandrolone

Chemical name

(17бета)-17-Гидроксиэстр -4-ен-3-он (in the form of kaproata, ziklotata, dekanoata)

Gross

C18-H26-O2

Characteristics

White kremovatam with white crystalline powder. Nerastvorim water, poorly soluble in alcohol.

Of drugs

The drugs-androgennoe, anabolicescoe, protivoanemicescoe, protivoopujolevoe. Associated with specific belkami-retseptorami on the surface of cells Organs, constitute retseptor-nandrolon providing transport of the cell envelope in gialoplazmu where it diffuses through the nuclear membrane in the cell nucleus and the activation of genov-regulyatorov. Androgenne properties are to stimulate the synthesis of nucleic acid (DNA, RNA), structural proteins, woven increased respiration and oxidative fosfaurilirovania in skeletal muscles of retention makroergov (APF, kreatinfosfata); Increases muscle mass and reduces the amount of adipose tissue. Accelerate growth of male sexual organs and the development of the secondary sex characteristics of a male. Is calzificace growth zones in the bones and a skeletal growth. Does secretornuu activity androgenzawisimah glands-male sex (activation process spermatogeneza), tallow; In high doses is supresshiyu Ladiga cells and reduces the synthesis of endogenous sex hormones through oppression of gipofizom opened and LG (negative feedback). Anaboliceski effect is activated sh processes epitelia (pokrovnom and gelezistom), bone and muscle tissues as a result of stimulation of protein synthesis and structural components of cells. Increases full absorption of amino acids small bowel (in the face of a diet rich in protein), a positive balance of nitrogenous. Does a Erythropoietin and activates anabolic processes in the marrow that while the appointment of iron is protevoanemicakim action. Violate synthesis of vitamin K-zawisimah plasma of blood clotting (II, VII, IX, X) in the liver, fat alters plasma profile (increased concentration of engineers and reduces the LPVP) reabsorbqiyu increased sodium and water in the kidneys, contributing to education peripheral oedema. After the / m of 100 mg C_max up after 1-3 weeks. Treated biotransformation in the liver education 17-ketosteroidov. Write mainly via the urine (more than 90%) and about 6% from faeces.

Indications

Chronic infectious diseases, injuries, extensive operational intervention steroidnaya miopatia, anaemia in chronic renal failure and mielofibroze, mielosclerose, mieloidna aplazii bone marrow (refrakternae to the usual therapy), losing bone marrow metastases of malignant neoplasms, mielotoksicskimi drugs and salts of heavy metals; neoperabelnaya (with cancer) cell breast cancer among women in postmenopauzne period or after ovarioektomii; stunted growth of children as a result of a deficit somatotroponogo hormone.

Contraindications

Cell hypertrophy, or prostate cancer, malignant tumours breast men carcinoma breast cancer among women with gipercalziemiei (to activate osteoclasts and cause resorption of bone tissue), pregnancy (the embriotoksicnostthew, fetotoksicnostthew could cause musculinizatiou female foetus), IBS expressed arteriosclerosis; Heart failure and the others accompanied by otecnam syndrome, acute and chronic liver disease, including alcoholic destruction, jade, principally syndrome, breast-feeding (it is necessary to abandon breastfeeding).

Side-Effects

Men and women, the progression of atherosclerosis (an increase of engineers and the decline of LPVP), iron deficiency and peripheral oedema, diarrhoea disorders (pains in the abdomen and epigastralna area, nausea, vomiting), disruption of the liver with jaundice, leikozopodobnyy syndrome (changes in leukocyte formula pain in the long tubular bones), gipokoagulyatsia with a proclivity to the uterus, gepatonekros (dark stool, vomiting, with some blood, headache, a feeling of discomfort, breathing problems), gepatozellliarnaya carcinoma, liver purpura (dark urine, stool discoloration, urticaria, or point makulezne hemorrhagic skin rash and mucous shells, pharyngitis or tonsillitis), holetsaticeski hepatitis (yellow staining skler and skin, pain in the right podreberie, temnookrashennaya urine, kurutulmuş chair). The women virilizm (increase clitoris, brutalization vote, and get amenorea, hair growth on the male type), gipercalziemia (CNS oppression, nausea, vomiting, fatigue). Men : in prepubertatne period, virilizm (acne, increase penis, priapizm, the formation of secondary sexual characteristics), idiopathic hyperpigmentation skin, slow or halt (calcification epifizarnah grown zones tubular bones); In postpubertatne period, irritation bladder (increasing frequency sneeze), chest tightness glands, ginekomastia, priapizm, into old age, hypertrophy and / or carcinoma of prostate cancer.

Patient interaction

Glukokortikoida, mineralokortikoida, kortikotropin, sodium products and foods rich in sodium, potenziruut (mutually) delay fluid in the body, increasing the risk of swelling, increase the severity vsapani acne. Do antiagregantov effects, anti proximity, insulin and oral protivodiabeticakih funds (oppressing their biotransformatia) - weakening dollar and its derivatives (up mineralization epifizarnah growth zones tubular bones). Impact gepatotoksicnosti other medicines.

Dosing and Administration

B / m depth. Nandrolona decanoate : with anaemia (at the same time as producing iron), 200 mg (women 50-100 mg) once a week; To stimulate anabolic processes 50-200 mg (women 50-100 mg) every 1-4 weeks; Children 2-13 years, 25-50 mg every 3-4 weeks. Time course (with 1-4-nedelnom between injection), through 12 weeks, a second course-by 8 weeks after the last injection into. Treatment out against the backdrop of a rich protein diet. When carcinoma breast (nandrolona fenpropionat) - 50 mg once a week; Length of individual.

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