Silabolin

Chemical name

Estren-4-ol-17beta-on-3 trimetilsililovy broadcast

Gross

C21-H34-O2-Si

Characteristics

White kremovatam with white crystalline powder. Virtually nerastvorim water, it is difficult soluble in alcohol.

Of drugs

The drugs-anabolicescoe. Working with specific receptors on the surface of cells Organs infiltrates the zitoplazmu the kernel, which activates the synthesis of DNA, RNA, and structural proteins. It stimulates the enzymes respiratory chain fabric increases respiration and oxidative Tiofat increases the accumulation of cells and glycogen makroergov. Impact katabolicescie effects glucocorticoids. And protevoanemicakim effect increasing Erythropoietin products. Protiwallergiceski effect was due to higher concentrations of inhibitor S_1-esterzy and, as a result, increases in the concentrations of S_2 and S_4 complement fractions. Increases the somatotroponogo hormone in the blood. Destroyed acid contents of the stomach, it only applies to / m. After a single injection has extended effect (10-14 days). Biotransformiroetsa in the liver. Metabolites derived mainly kidneys.

Indications

Chronic infection, trophic ulcers, burns disease traumas gipoplastical and aplastic anemia, palliative treatment of cancer of the breast for women in postmenopauzne period preventive treatment often retidivirutego angioneuroticeski oedema deficit antitrombina III of growth caused by insufficient somatotroponogo hormone, Turner syndrome, glukokortikoidnaya miopatia.

Restrictions on the use of

Heart failure, a breach of the liver and kidney, cardiac infarction, arteriosclerosis coronary arteries, diabetes mellitus, clean giperplazia prostate cancer, pregnancy, breast-feeding.

Contraindications

Breast cancer in women with gipercalziemiei, breast cancer in men, severe abnormalities in the liver and kidney cancer prostate, gipercalziemia.

Side-Effects

For women, and boys have prepubertatne age, the boys in postpubertatne age-dysfunction bladder with faster urinate, ginekomastia, priapizm; Iron deficiency and peripheral oedema, diarrhoea phenomenon of the liver, leikemical reaction, the tendency to bleeding. The women gipercalziemia, boys have prepubertatne age-unexplainable dark skin, men senilland age-hypertrophy and prostate carcinoma cancer; Necrotic liver damage, gepatozellliarnaya carcinoma.

Patient interaction

Do therapeutic effects of proximity and anti antiagregantov collateral-gepatotoksicnah funds delay sodium and water glukokortikoidami, mineralokortikoidami and somatotropinom. Gipoglikemicescuu lowers insulin activity.

Dosing and Administration

Adults - 1-1.5 mg / kg / month, children up to 1 mg / kg / months Monthly dose is divided into equal parts and give / m every 7 or 14 days (2-4 receiving). The course of treatment is 1-2 months. If necessary, repeat a course after a break of one month.

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