Mildronat

Roman name

Mildronate #

The composition and the form of

1 ml solution for injection contains mildronata 100 mg; Injection in 5 ml, in blistere 5 pcs. , in a cardboard bundle two blister.1 capsule contains mildronata 250 mg; blistere in 10 pcs. ; in a cardboard bundle 4 blisters.

Of drugs

Mildronat-structural analogue u-butirobetaina-carnitine predecessor. The preparation, ingibiruya у-бутиробетаингидрок��илазу (inhibiting the enzyme activity), reduces biosynthesis (education in the body) and carnitine transport long-fatty acids in skin cells prevents the accumulation in the cells activated forms of oxygenated fatty acids derived atilcarnitina and atilkofermenta A, thus preventing harmful effects. The declining concentration kartinita heavily synthesized u-butirobetain with vazodilatiruushimi (sosudorasshiratmi) properties.

Pharmacokinetics

The ingestion well absorbed. Bioavailability of approximately 78%. C_max-in 1-2 hours T_1/2 3-6 hours

Farmakodinamika

Lowers the level of carnitine transport and long-atilov through cell membranes by preventing the accumulation of activated forms of oxygenated fatty acids. With Cerebral warns of transport and ATP activates glikoliz. Increased content gamma-butirobetaina providing vazodilatirtee effect. In acute myocardial infarct slows necrosis tissue shortens the rehabilitation period. In heart failure improves airway diseases increases the portability of loads. Promoting physical fitness, reduces mental and physical stress. Activates cellular and humoral immunity. Alleviate abstinence syndrome in chronic alcoholism.

Indications

Angina, myocardial infarction, chronic heart failure, cardialgia against malnutrition infarction (composed of combination therapy); Acute and chronic violations of cerebral circulation (composed of combination therapy); Gemofthalm and bleeding in the retina of different etiology, thrombosis central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertension); abstinence syndrome in chronic alcoholism (in combination with a particular therapy alcoholism); reduction of efficiency and physical longevity.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Not established. Patients with chronic liver disease and kidney failure caused by prolonged use of the drug should proceed with caution.

Side-Effects

In rare cases, skin itch, despepsiceskie phenomenon (eating disorders), tachycardia (ucaschenne heartbeat), the institution, a change in blood pressure.

Patient interaction

Do the cardiac glycosides, nitroglycerin, nifedipina, бета-адреноблокаторо�� etc. antigipertenziveh and koronrodilatatorov.

Overdosing

Cases overdose unknown.

Precautions

Caution must be exercised in the appointment in conjunction with the hypotensive and коронародилататорами .

Dosing and Administration

Inside, in / in and / M.stabilnaya Drinking : on the inside of 250 mg three times a day for 3-4 days, then twice a week for half months (composed of combination therapy). The unstable stenocardia, myocardial infarction : in / in, struino 500 mg once a day, followed by both stable Stenocardii.cardialgia : inwards 250 mg twice a Sutki.ostrae of cerebral circulation : in / in, 500 mg once a day; chronic violations : in / m 500 mg once a day or on the inside of 250 mg 1-3 times a day (as part of an integrated treatment). Vascular pathology and dystrophic diseases of retina : parabulbarno, 50 mg / day for 10 Dn.hroniceski alcoholism : in / in or / m 500 mg twice a day, or the interior of the 500 mg four times a day during 7-10 Dn.dla increase the work : the interior, 250 mg four times a day for 10 to 14 Dnei.sportsmenam : on the 500 mg inside twice a day for training (in the morning); course, the competitions during the 14-21 day period in the competition-10 to 14 days.

Storage conditions

caps. : List B. In dry mester-r d / in. : List B. At room temperature

Shelf life

caps. : 4 gu.r-r d / in. : 4 g.

Indications for use

Adults to improve endurance for endurance, reduce phenomena physical and mental strain, including the athletes, in vostanovitionay period to expedite rehabilitation (restoration of disturbed functions of the organism) patients in aftercare period. (See also p. 168).

Form of

Capsule to 0.25 grams per pack to 10 capsules; 10% solution in sealed to 5 ml (0.5 g) in the package to 5 vials.

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