Mildronate

Chemical name

3-(2,2,2-Триметилгидрази��ий) propionat (Monohydrate)

Gross

C6-H14-N2-O2

Characteristics

The white crystalline powder with weak smell. Easily soluble in water, it is difficult to alcohol. Gigroskopichen.

Of drugs

The drugs-cardioproteguoe, antianginalnoe, antihypoxia, angioproteguoe. Is structural analogue gamma-butirobetaina (predecessor carnitine), and inhibits the synthesis of the latter. Reduce the level of carnitine transport and long-atilov through cell membranes, prevents the accumulation of activated forms of oxygenated fatty acids. With Cerebral warns of transport and ATP activates glikoliz. Increases gamma-butirobetaina content provider vazodilatirtee effect. In acute myocardial infarct warns necrosis tissue shortens the rehabilitation period. Against the backdrop of heart failure improves airway diseases. Increases portability physical labour and stimulates physical and mental fitness. Increases cellular and humoral immunity. Alleviate abstinence syndrome in chronic alcoholism. The ingestion well absorbed. C_max-in 1-2 hours T_1/2 3-6 hours

Indications

Angina, myocardial infarction, chronic heart failure, cardialgia against malnutrition attack, a breach of cerebral circulation, reduction of mental and physical performance, including the athletes posleoperazionny period to accelerate rehabilitation.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Organic defeat CNS, pregnancy and breast-feeding.

Side-Effects

Neuralgia, causing tachycardia, gipotenzia, itching.

Patient interaction

Do effects of cardiac glycosides, nitroglycerin, nifedipina, бета-адреноблокаторо�� etc. antigipertenziveh and koronrodilatatorov.

Dosing and Administration

Inside, in / in and / m. A stable stenocardia, on the inside of 250 mg three times a day for 3-4 days, then twice a week for 1.5 months. The unstable stenocardia, myocardial infarction, in / in struino 500 mg once a day, then both in a stable stenocardia. Cardialgia - inwards to 250 mg twice a day. Severe violations of cerebral circulation in / in, 500 mg once a day, standing in the / m 500 mg once a day or on the inside of 250 mg 1-3 times a day. To improve efficiency, the interior, 250 mg four times a day for 10 to 14 days. Athlete on the 500 mg inside twice a day for training (in the morning); Course, the competitions during the 14-21 day period in the competition-10 to 14 days.

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