Trimetazidine

Chemical name

1-[(2,3,4-Триметоксифенил )метил]пиперазин (as dihydrochloride)

Gross

C14-H22-N2-O3

Of drugs

The drugs-antianginalnoe, antihypoxia, zitoproteguoe, metabolicescoe. Directly affect cardiomiotita neurons and the brain, optimizing their metabolism and functions. Zitoprotectia due to sufficient energy capacity, activated oxidative decarboxylation, and the rationalization of oxygen (increased aerobic glikoliza and blockade oxidation of fatty acids). Maintained airway diseases, prevents Intracytoplasmic ATP depletion and fosfokreatinina. In azidoza normalizes functioning ion channels membranes, prevents the accumulation of calcium and sodium in cardiomiotitah, normalizes Intracytoplasmic Kalia.polnostthew content and is rapidly absorbed from the digestive tract and easily passes through gistogematicalkie barriers. Almost half by the number is biotransformation. T_1/2 about 6 p.m. 51% output unchanged to Pockami.umenishaet vnutricletocny acidosis and phosphates, from heart disease and reperfuziei. Prevents povrejdatemu Effects of free radicals preserves the integrity of cell membranes, prevents activation Klebsiella in the Cerebral increases the electrical potential, reduces withdrawal CPK from cells and the severity of ischaemic injury Miocarda.pri strokes reduces the frequency of attacks (reduced consumption of nitrate), in 2 weeks treatment increased tolerance to physical activity, reduced variable Ad.ulucchaet hearing and the results of vestibular samples from patients with pathology Lor-organov reduces dizziness and noise in the ears. In vascular pathology eye restores functional activity retina.

Indications

IBS, stenocardia, ischemic cardiomyopathy (composed of combination therapy), horioretinale vascular violations uproar in the head, dizziness (vascular violations Ménière disease).

Contraindications

Hypersensitivity, pregnancy, breast-feeding (nursing mothers should stop breast-feeding).

Side-Effects

Nausea, pain in epigastralna areas exposed skin.

Dosing and Administration

Inside, at the time of delivery, 1 tab. three times a day.

Literature

1. Thomas OM Trimetazidin (preduktal). The new approach in the fight against heart disease / / Ter. archive-1996 .- T. 68 N-8 .- C. 57-63.2. Manchanda S. Krishnawami C. Combined treatment stable stenocardia and trimetazidine дилтиаземом//Междунар . med. Zh-1998-N 5 .- C. 415-422.3. Stanley C., G. Lopaschuk, J. Hall, G. McCormack Regulation of myocardial metabolism carbohalrate under normal and ischaemic conditions. Potential for pharmacological investigations / / Cardiovascul. Res-1997 .- V. 33 N-2-P. 243-257.

Directory → Metaboliki → Antigipoksanta and antioxidants → Trimetazidine