Amifostine

Chemical name

S-[2-[(3-Аминопропил)амин о]этил]дигидрофосфоти оат

Gross

C5-H15-N2-O3-P-S

Of drugs

The drugs-zitoproteguoe. Protects cells is not involved in the Cancer growth of the zitotoksicski Dnk-svazavath protivoblastomnah funds : alkiliruth (ziklofosfan etc.), some synthetic (platinum) and antibiotics (mitomicin C). After the on / in Infusion quickly defosfauriliruetsa (with the participation of alkaline phosphatase) to free tiola (the active metabolite), and then to inactive disulfidnyi metabolita. After minute infusions in the dose of 910 mg / m ^ 2 C_max is 200 micromole per litre, active metabolita-35 micromole / l; Poluraspredelenia period is less than 1 min, T_1/2-not more than 10 minutes, the volume of the seven-litre, Cl-2 l / min. After six minutes after the plasma is less than 10% rate imposed through 5-8 min concentration of the active metabolita cells in the bone marrow than concentration in plasma several times. Return with urine (including in the form of metabolites). Warn a gemato-, nefro-, neiro- and ototoksicskih complications in the use of chemotherapy.

Indications

Prevention gematotoksicnosti Dnk-svazavath funds nefro-, neiro- and ototoksicnosti platinum drugs.

Restrictions on the use of

Expressions of the liver and kidneys, and children aged (over 70 years old) age.

Contraindications

Гиперчувствительност ь (including links to aminotiola, mannitu), arterial gipotenzia, dehydration, pregnancy, breast-feeding (at the time of treatment should be suspended).

Side-Effects

Transient decrease AD least Improvement Dad, loss of consciousness, skin person accompanied by the sense of heat, nausea, vomiting, icota, dizziness, drowsiness, sneezing, reduced concentration of calcium in blood serum, allergic reactions (skin rashes, eozinofilia, runs with a sense of cold, etc.).

Specific guidance

Cooked solution store no more than six hours at room temperature (15 to 25 ^ C), or more than 24 hours, at a temperature of 2-8 ^ C.

Patient interaction

Products of hypertension hypotension, including antigipertenzivee may strengthen decline AD.

Overdosing

Many expressed arterial Gipotenziei.lechenie : symptoms : patient attach the Trendelenburga, introducing / in isotonic saline solution.

Precautions

During the patient must be in the deck on the back. Infuziu out with a significant reduction in AD. Using against himiopreparatov causing vomiting, it is recommended that the admission of antiemetics (immediately prior to or during the infusions) and the control of fluid balance at the time of treatment. The risk gipocalziemii, incl. in the case of nefroticski syndrome, it is necessary to monitor the level of calcium in blood serum (preferable monitoring). Associated antigipertenzivnuu therapy cancel 24 hours before the introduction.

Dosing and Administration

B / infuzionno in-1 once a day for 15 minutes, 30 minutes prior to the imposition of химиотерапевтическог о tools; Recommended starting dose in adults-910 mg / m ^ 2. Before the introduction of 0.5 g liofilizirovannogo powder (the contents of one bottle) raise of 9.5 ml of sterile 0.9% solution of sodium chloride. Infuziu are under the control of AD (plus monitor). By reducing the baseline Sad from 100 to 20 mm Hg, with the 119 at 25 mm Hg, 120-139 with 30 mm Hg, 140-179 with a 40 mm Hg , or from 180 to 50 mm Hg, a cut of 5 min. If during this period the Sad returned to the original condition and the patient is deteriorating, infuziu started in the same dose, in other cases, reduce dose to 740 mg / m ^ 2.

Directory → Metaboliki → Detoksicirute means, including ComSP → Amifostine