Uric folinate

Chemical name

Calzieva salt N-[4-[[(2-амино-5-формил-1,4, 5,6,7,8-гексагидро-4-оксо- 6-птеридинил)метил]ами но]бензоил]-L-глутамин��вой acid (and as pentahydrate salt)

Gross

C20-H21-Ca-N7-O7

Characteristics

Jeltovato-bely crystalline powder. Easily soluble in water, sensitive to light.

Of drugs

Drugs, the lack of complementary folic acid catalyst in the rapidly updated fabrics, less toxicity methotrexate, gemopoeticescoe. Folic acid in the liver through appropriate folatreduktaz restored consistently digidro- and then tetragidrofolievu. Last as kofermenta a translokatia odnouglerodistah residues involved in biosynthese purinovykh and pirimidinovykh grounds as structural components of nucleic acids. Renowned protivoopujolevy-drug methotrexate, blocking folatreduktazu in Tumor Cells (mostly), a deficit tetragidrofolata and stops in proliferating tissues; Its effects are easily removed folinatom.

Indications

Metotrexatom intoxication (treatment and prevention), anemia megaloblastnye behaviours origin folinievy hypothesis and beri.

Contraindications

Hypersensitivity, pernitsiosnaya etc. megaloblastnye deficiency in the face of Vitamin B_12.

Side-Effects

Allergic reactions.

Specific guidance

Solution calcium folinata for infusions should prepare ex tempore; Use it only for 12 hours Bottles dry liofilizirovannam substance must be stored at a temperature not exceeding 25 ^ C.

Patient interaction

Ters effect of methotrexate (including therapeutic).

Precautions

When pregnancy and breast-feeding apply only as a last resort.

Dosing and Administration

V / m, / in for the 5 mg / day for 10 days. Using high doses of methotrexate calcium folinate appoint at 25 mg / m ^ 2 through 8 h after methotrexate, then every 6 hours for 4 days. Inside. After 24 hours after the methotrexate (in normal delivery) to 15 mg every six hours, or until the level of methotrexate in the plasma will not fall below 0.05 Mkm (with the slow delivery later).

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