Dextran

Chemical name

Polysaccharides, producyruemye of Sugar bacteria Leuconostoc mesenteroides

Of drugs

The drugs-plazmozameshchatee. Dekstrana are glucose polymers may have varying degrees of polymerization, depending on which solutions derived from them, have different functions. Solutions containing acid with relative molecular mass of about 60,000, are used as gemodinamicakih of rebuilding BCC. The high onkoticski pressure of onkoticescoe pressure plasma proteins 2.5 times, they are very slow to pass through the vascular wall, and a long time to move in line with sossoudistom normalize hemodinamics from current liquid on the concentration gradient from tissues in receptacles. As a result, rising rapidly and the long-term retention of the high-level AD decreases tissue swelling. Solutions containing weight dekstrana (30000-40000), used as a means of detoxification. In imposing them improves blood flow is reduced Aggregation loose elements. They also osmoticski mechanisms encourage diurez (filtered in clubockah create primary urine onkoticescoe high pressure and prevent the reabsorbtion water in the bone) than to (and faster) withdrawal from the body of poisons, toxins, degradation products exchange. The dekstrana toxic, excretiruyutza kidney in an unmodified form. In exchange uglevonom not participating. Some of the high-dekstranov when used in high doses can put in the cells retikuliarna system, which is metabolized to glucose.

Indications

High-dekstrana used to fill in the BCC krovopoteriah, shocks of different genesis. Dekstrana weight used in the various intoksikatziah, violations of rock properties of the blood and capillary blood flow, for the treatment and prevention of tromboflebitov and brutal conditions.

Restrictions on the use of

Trombozitemia.

Contraindications

Head trauma increases vnutricerepnogo pressure haemorrhagic stroke.

Side-Effects

Allergic reactions.

Dosing and Administration

Solutions of high-dextran give / in drip or (for the dramatic decline AD) on / in the dose of 400 to 1200 ml, in ojogovom shocked to 2,000 ml / sut. Children appointed dose of 50 ml / kg / sut. Solutions srednemolekularnah dekstranov infuziruut (within 30-60 minutes) in the case of shock dose of up to 1400 ml. To detoxification give / drip in 800 ml, in a few hours, if necessary, handling additional 400 ml.

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