Flumazenil

Chemical name

Этил-8-фтор-5,6-дигидро-5 -метил-6-оксо-4H-имидазо [1,5-a][1,4]бензодиазепин-3 -карбоксилат

Gross

C15-H14-F-N3-O3

Characteristics

White or almost white crystalline powder, insoluble in water and poorly soluble in acidic aqueous solutions.

Of drugs

Drugs, the blocking benzodiazepinove receptors. Competitive benzodiazepinove blocks receptors and withdraws central psychomotor effects of the substances, the incident. Neutralizes the snotvorno-sedativoe and restores self breathing and consciousness in the overdose of benzodiazepines. And internal agonisticescoy (vis-à-vis named receptors) activity (противосудорожной).Б��стро absorbed by Injecting introduction. The blood is associated with a protein of 50% (2 / 3 from albuminami). Average of 0.95 l / kg Total plasma Cl-1 L / min. T_1/2 is 50-60 min. The ethyl-carbonova acid is idle (or as agonist or antagonist as benzodiazepines). Fully (99%) presented with jelchew.

Indications

Addressing the central effects of benzodiazepines (including the withdrawal of narcosis, differential diagnosis overdose of benzodiazepines, unconscious unknown etiology and skull injury).

Contraindications

Гиперчувствительност ь.

Side-Effects

Tides blood to a person, fear, heart (with the rapid on / in the introduction), convulsions (with epilepsy in history), the symptoms of benzodiazepine withdrawal symptoms, rashes.

Patient interaction

Ters effects zopiclone, triazolpiridazinov, benzodiazepines.

Precautions

Is not recommended for human autonomic nervous or circulatory system during severe poisoning tri-and tetratziklicescimi antidepressants. It should appoint people with epilepsy receiving long-term benzodiazepines (possible provocation convulsing). During the 24 hours after application flumazenila should refrain from working with potentially dangerous machinery, driving and other activities requiring greater attention. In the first trimester of pregnancy received only works on the absolute condition in anaesthesia can be until the end of peripheral miorelaksantov. It should be borne in mind that in patients with severe craniocerebral (or unstable vnutricerepnam pressure) can develop more vnutricerepnogo pressure.

Dosing and Administration

B / in (pre razbaviv 5% glucose solution or 0.9% solution of sodium chloride). In anesthesiology, in the initial dose of 0.2 mg within 15 seconds; If necessary, to 0.1 g in 60 seconds and the total dose of 1 mg; Usual dose-0.3-0.6 mg. In intensive care in the initial dose of 0.3 mg; If necessary repeat injection every 60 seconds and the total dose of 2 mg.

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