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Calcium folinate

See also Uric folinate

Roman name

Uric folinate

The composition and the form of

1 ml solution for injection contains folinieva acid 2.5 mg (as folinata calcium); in 182,000,000 to 1 and 10 ml, in a carton five vials.

Of drugs

Complementary deficit folinieva acid gemopoeticescoe, stimulating growth quickly updated fabrics, less toxicity methotrexate. Having become folinievu (tetragidrofolievu) acid is involved in numerous metabolic reactions, primarily captures odnouglerodistah fragments.

Pharmacokinetics

After the / m of C_max-30 mines, T_1/2 about 45 minutes. To a large extent, linked to the tissues, out of the body in the kidneys.

Indications

Prevention eliminating metotrexatom (treatment of leukaemia and solid tumors). Megaloblastnye anaemia behaviours origin. Folinievy hypothesis and beri.

Side-Effects

Diarrhoeal disorders, allergic reactions.

Patient interaction

Ters effect of methotrexate (including therapeutic).

Dosing and Administration

V / m, / in for the 5 mg / day for 10 days. Using high doses of methotrexate calcium folinate appoint at 25 mg / m ^ 2 through 8 h after methotrexate, then every 6 hours for 4 days.

Storage conditions

r-r d / in. : List B. In the dark spot

Shelf life

r-r d / in. : 2 grams.

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