Kuprenil

Roman name

Cuprenyl

Pharmacokinetics

Rapidly absorbed from the digestive tract. C_max achieved through 1.5 hours Biotransformiroetsa in the liver. Report the news mostly in the form of metabolites. T_1/2 - 24-75 h.

Indications

Villson-konovalova disease, intoxication copper, mercury, lead and gold. Zistinovy stone, gemosideros, rheumatoid arthritis, sklerodermia, alcoholic cirrhosis with gepatomegaliei, fibroplasticski alternative therapy.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

The drug is not suitable for the high degree of sensitivity to penitsillino, pregnancy, radiation (reducing cells in the blood) and trombozitopenia (decrease in the number of platelets in the blood), severe kidney failure, bronchial asthma.

Patient interaction

One of the drugs, oppressive blood. Antimalarial drugs, levamisole and fenilbutazon increase the likelihood of side effects Kuprenila. Kuprenil antagonist is B_6 vitamin.

Precautions

Treatment Kuprenilom conducted under strict kliniko-laboratorian control. At the beginning of treatment are detailed (including platelets) clinical blood and the overall analysis of urine every three days, and then once a week. Every month should monitor the liver, kidneys, a neurological examination patient. In the case of development in the face of treatment Kuprenilom fever, lung disease, liver expressed haematological and neurological violations gravis, gematurii, volchanochnopodobnykh reactions and other serious side effects cancel product and, if necessary, appoint glukokortikoida. Patients with the disorder cold dose of the drug reduced. In the case of closed proteinurii if it is not growing, and not more than 1 g / day, the treatment can be Kuprenilom Prodoljiti.v the impact on Kuprenila collagenoobrazovanie, surgery (including dental) should be particularly осторожностью.Пациен��ам illness or Villson-konovalova zistinuriei while Kuprenilom appointed vitamin B_6 (in conjunction with nutritional limitations applicable to these diseases). In developing symptoms of Vitamin B_6 against the backdrop of long-term care insurance Kuprenilom further appoint 25 mg pyridoxine, in the case of Sutki.v the inefficiencies and the preparations gold Kuprenil appointed no earlier than June Mes.esli be patient appointment iron in the face Kuprenilom therapy, it should be the two interval between their admission.

Storage conditions

B. List in a dry place at room temperature (up to 25 ° C).

Shelf life

3 years

The registration

013649/01-2002

Of drugs

The basic premise of the kuprenila is its high compleksoobrazutaya activity in the metal ions. It links mainly ions mercury, lead and iron, and calcium. Both complexes are removed kidneys. The drug increases remove urine excess copper from tissue and is said to be more efficient than tiolove compounds (see Unitiol).

Indications for use

Kuprenil used for treatment of acute and chronic sending metal salts, as well as disease-Westphal Wilson-Konovalova (/ gepatotserebralna malnutrition / inheritance liver disease and the brain associated with the violation of proteins and copper). Assign kuprenil adults with various forms of rheumatoid arthritis (инфекционно-аллергич еской diseases from the group kollagenozov characterized by chronic progressive inflammation of joints), in the absence of effects from the use of conventional �ротивовоспалительны�� funds. Kuprenil regarded as one of the top ( "basic") means for the treatment of rheumatoid arthritis.

Dosing and Administration

Is drug inside the 2-2 1 / 2 hours after eating.

Side-Effects

In applying kuprenila offers different reactions. There may develop allergic reactions (skin, etc.), gastrointestinal disorders (loss of appetite, nausea, vomiting, diarrhea), gingivit (inflammation of mucous membranes inside), stomatitis (inflammation of mucous membranes of the oral cavity), the loss of taste. There lakopenia (to reduce blood in the blood), thrombocytopenia (decrease in the number of platelets in the blood), agranulozitos (dramatic decrease in the number of granulozitov in the blood), mialgia (pain in the muscles), artralgia (kneecap pain), the phenomenon of myasthenia (muscle weakness). With long-term use, there nefrotoksicnoe Effects (povrejdatee effects on the kidneys) : proteinurija (protein in the urine), gematuria (blood in the urine); In rare cases, volchanochnopodobnyy syndrome.

Form of

The capsules to 0.15 g.

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