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Lejkovorin ca lahema

See also Uric folinate

Roman name

Leucovorin Ca Lachema

The composition and the form of

1 bottle capacity of 20 ml with liofilizirovannam sterile powder for the preparation of injection solution contains calcium folinata 10, or 25 mg, as well as sodium chloride and sodium hydroxide (to maintain pH); in a box 10 bottles.

Indications

As an antidote to overdose and forced suspension metotrexatna therapy; Prevention of the side effects of methotrexate in his appointment in the medium and high doses.

Contraindications

Malignant and megaloblasticskie anaemia with dificitom B_12 vitamin.

Side-Effects

Allergic reaction to the high dose.

Precautions

The store (and use) lejkovorin divorced more than 12 hours

Dosing and Administration

In / in, in / m. Dissolved in 1 ml (2.5 ml) water d / in. In overdose methotrexate (as an antidote) : 1-10 mg / m ^ 2 every 3 hours before the disappearance of symptoms. You can be a 2-4 hour infusions of methotrexate (with the medium dose) for 5-40 mg / m ^ 2 every 2-3 hours during the 72 hours; Or (when high doses), 40 mg / m ^ 2 for 12 h, and then 10 to 15 mg / m ^ 2 every 3-6 hours

Storage conditions

In the dark place at a temperature of no higher than 25 ° C

Shelf life

2

The registration

011879/01-2000

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