Lithium edetate calcium

Chemical name

Calzi-dinatrieva salt edetinova acid

Gross

C10-H12-Ca-N2-Na2-O8

Characteristics

Clear transparent liquid pH 5,0-7,0.

Of drugs

The drugs-compleksoobrazutee, desintoksikatine. Is antidote in case of poisoning and heavy KPb elements and their compounds. Remove part of the compound calcium ions to dwuhvalentnykh and trivalent metals; With the result of low water-soluble compounds, quickly released from the body. Calcium can replace only ions of metals, which can displace it from the molecular structures : zinc, cadmium, iron, cobalt, mercury, uranium, ittriy, cerium, manganese, etc. Absorbiruetsa in blood trickles. In Injecting a fully associated with plasma proteins. It penetrates inside the cells is экстрацеллюлярно.Кон��ентрация in the spinal fluid of 5% of the plasma. T_1/2 - 20-60 min. Report unchanged to mostly kidneys (50% within 1 h, 95% within 24 hours).

Indications

Acute and chronic poisoning and heavy KPb metals (lead, cadmium, cobalt, mercury, uranium, vendors, etc.) and their compounds.

Contraindications

Personally, principally, the liver and kidneys, pregnancy, breast-feeding (should stop breastfeeding).

Side-Effects

Fever, chills, mialgia, artralgia, weakness, pain in the ground / m of acute necrosis Channel proximal, distal damage Channel and kidney clubocka, glukozuria, proteinurija, mikrogematuria and hypotension, violations of the heart rhythm, tremor, headache, ringing in the ears, encephalopathy (children), oppression bone marrow, anemia, nausea, vomiting, anorexia, thirst, sneezing, nose zalojennosti, slezotechenie, lower zinc content in the blood.

Specific guidance

During treatment significantly decreased activity of alkaline phosphatase.

Overdosing

Symptoms : increased side effects, swelling the brain, kidney necrosis tubulyarnyi deficit Cinka.lechenie : mannit (to reduce brain oedema), giving diureza, maintaining vital functions.

Precautions

To reduce the risk of side effects is recommended prior to the treatment adequately diurez and in the treatment of its support. It should warn patients of the need to inform the doctor in the event of a delay mocheotdelenia more than 12 C.oligouria, increasing the number of epithelium cells in the urine, increasing gematurii and proteinurii calling for the repeal Preparata.pri acute food poisoning metals introduction can be done only after cleaning tract (stomach wash, sifonne enema) since formed complexes with metal readily soluble and can be possessed by increasing symptoms Intokshikation.pri in / with the introduction of a monitoring ECG (possible disruptions). The appointment of iron and vitamin B_12 (for the normalization of hemoglobin).

Dosing and Administration

With minimal symptoms of poisoning (level toxic substances 70 µ g / m), adults and children, to 1000 mg / m ^ 2 per day / m or / 386/1989 In / in the drip : in izotonicescom solution of sodium chloride or 5% glucose solution in one dose of 2 g (20 ml 10% solution), a daily-4 grams daily for 3-4 days followed by a break of 3-4 days treatment 1 month.

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