Unithiol

Chemical name

2,3-Димеркаптопропансу льфонат sodium

Gross

C3-H7-Na-O3-S3

Characteristics

White or white with a slightly kremovatam melkochristalliceski white powder with a very light smell mercaptan. Easily soluble in water, not in the alcohol. Water Solution colourless or blushed transparent liquid with light smell mercaptan; PH 5% solution-3,1-5,5.

Of drugs

The drugs-desintoksikatine. Finally sulfgidrilnami groups linked to form a non-toxic water-soluble complexes with are in the blood and tissues of poisons that can interact with sulfgidrilnami (tiolovmi) groups enzymes and inachtivirovti them. Used as antidote to poisons arsenic compounds and salts of heavy Metallov.pri Injecting a rapidly absorbed in the blood. C_max achieved through 15-30 minutes after the / m injection. T_1/2 1-2 hours Excreted kidneys, mainly in the form of products of incomplete and complete oxidation, partly in an unmodified Vide.prerne tying unitiola with blokatorami sulfgidrilnykh groups and the rapid removal of the resultant complexes cautions tying tiolovykh groups enzymes and the rebuilding of their activity, resulting in diluted or eliminated the symptoms of poisoning. Increases down of some cations (especially copper and zinc) of enzymes containing cells. Patients who are diabeticakimi polineiropatiami and secondary amiloidozom reduces pain syndrome, the improvement of the peripheral nervous system and the normalization of capillary permeability.

Indications

Acute and chronic poisoning organic and inorganic arsenic, mercury, gold, chromium, cadmium, cobalt, copper, zinc, nickel, bismuth, antimony; Intoxication cardiac glycosides, gepatotserebralnaya degeneration (Wilson disease-Konovalova), diabetic polineiropatia, chronic alcoholism.

Contraindications

Hypersensitivity, severe liver disease, hypertension.

Side-Effects

Nausea, vomiting, tachycardia, hypertension, dizziness, anxiety.

Specific guidance

In acute poisoning mandatory etc. disease (stomach scene, the introduction of glucose, oxygen inhalation).

Patient interaction

Farmatsevticeski incompatible with preparations containing heavy metals leaching (quickly broken).

Dosing and Administration

Inside, in / m, c / GMT Poisonings arsenic compounds and mercury : adults, in the / m, c / to : 5-10 ml (at the rate of 0.05 mg or 1 ml of 5% solution of 10 kg body weight), on the first day 3-4 injections every 6-8 hours, in the most severe cases, up to eight users; On the second day 2-3 injections every 12 hours; in the next day or injections. Inside, in the 100-150 ml of 5% solution for washing stomach on the first day. Children in / m, 1 ml of 5% solution of 10 kg body weight on the first day at 6900, in the next day 1-3 injections. The application depends on the speed of removing toxic compounds from the body. Treatment spend up to the disappearance of signs of intoxication. When poisoning mercury salts to the introduction of at least six days. Intoxication cardiac glycosides : in / m, c / to 5-10 ml 3-4 times a day during the first two days and then two times a day before the disappearance cardiotoksicski actions; Gepatotserebralnaya degeneration : in / m, 5-10 ml of 5% solution every day or every other day course of injections 25-30 with a break between courses 3-4 months; Polineiropatia diabetic : 5 ml within 10 days; chronic alcoholism : in / m, in the 3-5 ml 5% solution 2-3 times a week. For cupping the deliria drink in / m, 4-5 ml of 5% solution.

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