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AravaSee also LeflunomideRoman nameAravaThe composition and the form of1 tablet coated liner contains leflunomida 10, and 20 mg; in polyethylene bottles to 30 or 100 pc. , in a cardboard bundle one bottle, or 100 mg; in blistere 3 pcs. , in a cardboard bundle one blister.Of drugsImmunodepressivne, antiproliferativoe, противовоспалительно е. Oppresses дигидрооротатдегидро геназу.PharmacokineticsThe blood absorbed by 82-95%. Quickly and completely transformed into an active metabolite A771726, which makes therapeutic effect. C_max for A771726 is in the range of 1-24 hours Virtually all contact albuminom blood. Return slowly T_1/2 is about two weeks. Provided with faeces (in the unedited version) and urine (partly in the form of metabolites).Clinical pharmacologyTers signs and symptoms of rheumatoid arthritis. The effect manifests itself after one month to cease around 3-6 months and maintained throughout the course of treatment.IndicationsRheumatoid arthritis (active form).Pregnancy and lactationContraindicated.ContraindicationsHypersensitivity, AIDS expressed by the human bone marrow (not resulting from rheumatoid arthritis), severe infectious diseases, kidney failure, a breach of the liver, severe gipoproteinemia, including in nefroticescom syndrome.Side-EffectsThe AD, diarrhea, nausea, vomiting, anorexia, disease nasal cavity (mouth disease, izgyazwlenia lips), pain in the abdomen, the liver (more transaminaz, alkaline phosphatase, cium), a small loss of body mass index, headache, dizziness, fatigue, paresthesia, tendowaginit, increased hair loss, eczema, dry skin, lakopenia, skin rashes, itching, allergic reactions, typical of (1-10% of patients). Gipokaliemia breach of taste, anxiety, a links syndrome Stevens-Johnson, toxic It'sa nekroliz, mnogoformnaya erythema, anemia, thrombocytopenia, urticaria, atypical of (0.1-1%). Serious liver, eozinofilia, pancitopenia-rare for (0.01-0.1%). Heavy �нафилактические/анаф илактоидные reaction agranulozitos very rarely (less than 0.01%).Specific guidanceThe agent should be appointed experts with the necessary experience in the treatment of rheumatoid arthritis.Patient interactionSide-effects are increased gepato- and gematotoksicnae drugs. Kolestiramin and activated carbon weaken effect.PrecautionsWomen of child-bearing years at the time of treatment must use reliable methods of contraception (prior to the beginning of the course to be sure that there is no pregnancy). Women wishing to become pregnant should stop receiving medication and to the wash : reception kolestiramina to 8 g three times a day or activated carbon to 50 mg four times daily for 11 days. Prior to the reception of another противоревматическог о preparation (eg methotrexate), or to a planned pregnancy also needed the procedure described above periods. At the time of therapy to refrain from vaccination living vaccines and receive alcohol.Dosing and AdministrationThe inside is not liquid, squeezed enough liquid, 100 mg for 3 days (shock dose), and then on 10 to 20 mg once a day for 6-12 months.Storage conditionstabl.p.o. : At temperatures below 25 ° CShelf lifetabl.p.o. : 3 and |
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