Carniten

Roman name

Carnitene #

The composition and the form of

1 USD 5 ml solution for injection contains L-karnitina hydrochloride 1.23 g (corresponding to 1 g of carnitine); in a contour acheikova package 5 pcs. , in box 1 upakovka.1 feet from 10 ml for admission into the L-karnitina hydrochloride 1 g; in a box 10 st.1 chewable tablet contains L-karnitina hydrochloride 1 g; in a contour bezgyachakova package 5 pcs. , in box 2 packaging.

Of drugs

Anabolicescoe, antihypoxia, regenerating, antitireoidne.

Pharmacokinetics

Easily absorbed from the intestine, penetrates into all fabrics, the greatest concentrations are in the skeletal muscles and miocarde. C_max achieved after 3 h, and has remained at the level of department by 9:00 Kidney excreted unchanged to the (more than 80% in 24 hours).

Farmakodinamika

Is penetration fatty acids, long chain in the mitochondria and their participation in beta-oksigenation regulates activity адениннуклеотидтранс локазы and supervises operations generated muthondriami energy zitoplazmu. Regulate fat and protein exchange, oppressing education and ketokislot anaerobnyy glikoliz, reduces lactoatsidoza increases motor activity, and raised the threshold of acceptability physical labour, reduces excess weight and reduces the fat content in miotitah.

Indications

Inherent primary and secondary carnitine deficiency; Acquired secondary carnitine deficiency in the total Injecting nutrition, chronic gemodialise, admission valproeva acid intensive physical work; Prematurity, stunting and body weight, perinatal pathology of central nervous system in newborns and premature; Stenocardia, acute myocardial infarction, cardiogenny shock postinfarctne condition of the peripheral arteries.

Pregnancy and lactation

Without limits.

Contraindications

Гиперчувствительност ь to the drug.

Side-Effects

Digestive disorders (after receiving inside), light miastenicescie symptoms (in patients with uremyei).

Dosing and Administration

In / in slowly. Secondary deficit in gemodialise : 2 g once (after the procedure); Acute myocardial infarction : 100-200 mg / kg / day 4 admission or continued introduction of the first 48 h and then declining doses twice; Cardiogenny shock : in / in before the patient from Shoka.vnutri, single dose bottle of diluted drink water. Primary and secondary deficit with genetic diseases : children under 2 years of age-150 mg / kg / day, 2-6 years, 100 mg / kg / day, 6-12 years, 75 mg / kg / day of 12 years, and adults, 2-4 g / kg / day; Secondary deficit in gemodialise : 2-4 grams per day; Drinking and the posleinfarctne : 2-6 grams per day.

Shelf life

r-r d / in. : 4.5 gu.r-r reception inside : 5 lettabl.jev. : 3 and

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