Lactulose

Chemical name

4-O-бета-D-Галактопиран��зил-D-фруктоза

Gross

C12-H22-O11

Characteristics

White powder dissolves easily in water. The impurities may contain galactozu (not more than 16%), lactose (12%), ephylactozu (8%), fructose (1%).

Of drugs

The drugs-slabitelnoe enabling irritative bowel. Does reproduction molernkislah bacteria and irritative bowel (only in colon cancer). Micro large bowel hydrolyzation lactoulozu to dairy (mainly), and partly to formic and acetic acids. The KISR increasing pressure and acidified contents of the bowel, resulting in the retention of ammonium ions is migration of ammonia from the blood in the rectum and ionization. Oppressing education and the removal of nitrogen toxins in the proximal section large bowel. Decreases the concentration of ammonium ions in the blood of 25% -50% and reduces the severity gepatogenna encephalopathy, improves mental condition and normalizes Eeg.vvedenie of nitrate ions in the development slabitelnogo effect. Step is a 48 h after injection. His otsrocennosti from passing through drug stomach. Components lactoulozy poorly absorbed in the blood and their daily withdrawal with the urine of about 3%.

Indications

Siegenia (including chronic), hepatic encephalopathy, including to whom and prekomu (treatment and prevention), the intestinal flora (eg, salmonellezah, shingellezah, etc.) syndrome gnilostna dispepsii in infants, pain syndrome after removal gemorroidalnah knots.

Contraindications

Hypersensitivity, galactosemia.

Side-Effects

Diarrhoea, flatulence, loss of electrolytes.

Patient interaction

Antibiotics (components) and neabsorbiruemye antatsida less effect.

Precautions

Be wary apply diabetes. The elderly and handicapped patients receiving lactoulozu more than 6 months, it is recommended to periodically measure electrolytes in whey. In gastrocardialnom syndrome should gradually increase the dose to avoid meteorism. Flatulence usually disappears to the 2-3 days of treatment. Do not assign to a pain in the abdomen, nausea and vomiting. When diarrhoea treatment hereof.

Dosing and Administration

Inside. When liver encephalopathy adults to appoint 45-90 ml syrup 2-3 reception on the other eyewitness accounts, 15-45 ml / sut. Children over the age of one year, 15 ml, aged 1 year to 5 ml / sut.

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