Levocarnitine

Chemical name

3-Карбокси-2-гидрокси-N, N,N-триметил-1-пропанам��ния hydroxide (inner salt)

Gross

C7-H15-N-O3

Characteristics

The white crystalline powder and odourless, easily soluble in water, very soluble in alcohol.

Of drugs

The drugs-anabolicescoe, antihypoxia, antitireoidne, stimulating fat exchange, regenerating. Refers to a group of vitamin B (B_t-vitamin growth). Is kofactorom metabolic processes that sustain activity Koa. Provides anabolicescoe action reduces the exchange, slows the breakdown of protein and carbohydrate molecules. Is cross-mitochondrial membrane and split long-fatty acids (palmitic, etc.) with the formation of Azetil-koa (necessary for the activity piruvatcarboksilazy in glukoneogeneza, education ketonovykh bodies synthesis of choline and its esters oxidative fosfaurilirovania and education APF). Provides jiromobilizutee effect as a consequence of the unstable three methyl groups. Competitive displacing glucose includes jirnokislonetary shunt metabolic activity is not limited oxygen (as opposed to aerobic glikoliza), and it is effective in acute cerebral hypoxia and other critical states. It is a slight oppression CNS increases secretion and fermentativuyu activity digestive juices (gastric and intestinal), improves assimilate food. Reduces excess weight and reduces the fat content in muscular. Increases threshold resistance to physical activity leads to the elimination of poslenageorgerngo azidoza and, as a result, the restoration work after long debilitating physical loads. Increases stocks glycogen in the liver and muscles, contributes to a more economical use. Provides neirotroficescoe action slows development apoptosis limits zone defeat and restores the nervous tissue. The plasma adults and older children ranging carnitin found in a concentration of 50 micromole / O The ingestion well absorbed, the plasma reaches a peak after 3 h in a therapeutic range for 9 hours When the / m found a plasma during 6700, after the / in the application in less than three hours disappeared from the blood. Easily penetrate liver and miocard, slower in the muscles. Report the news mostly as acyl esters.

Indications

The birth trauma and asphyxia newborns, wasting and hypotension newborn, respiratory distress in newborns, nursing of premature births in full Injecting nutrition, and children, who are Hepatology; Sindromokomplex similar to the syndrome Rayee (hypoglycaemia, gipoketonemia, coma), evolving from children against the backdrop of the admission valproeva acid; deficit body mass index in children and adolescents under 16 years of age; 2,4,6 etc. organic azidemii, primary (genetic), and secondary carnitine deficit, including in patients with chronic renal insufficiency in gemodialise; minor tireotoxicoza forms, экзогенно-конституци��нальное obesity, psoriasis, seborrhea, skin forms sclerodermia, cardiomyopathy, myocarditis, heart (stenocardia, acute myocardial infarction, postinfarctne), a gipoperfuzia cardiogennom in shock, myo, anorexia, chronic gipoatsidnye gastrita, chronic pancreatitis in violation of the exocrine function, liver disease, nevrastenia, traumatic encephalopathy, physical exhaustion, the intense exercise of athletes (as anabolika and adaptogene) cardiotoksicnosti prevention in the treatment of antratziklinami.

Contraindications

Гиперчувствительност ь.

Side-Effects

Pain perception in epigastralna areas of diarrhoea, muscle weakness.

Patient interaction

Glukokortikoida to accumulate in the tissues (except liver), etc. anaboliki added effect.

Dosing and Administration

Inside, in / 386/1989 Inside, 30 minutes before the delivery, lemons water, tea, kiselem, adults 2-3 times a day by 1/2-2 c.logki 20% solution or 1-2 chewing table. For ease of use in newborns to use throw 3 ml of 20% solution of 200 ml of 5% glucose solution and the solution obtained appoint 10-20 ml (c.logki 2-4), 2-3 times a day for 30 minutes before feeding. At the end of the newborn to 1 year appoint 10 drops of 20% solution for children 1-6 years, to 14 drops, 6-12 years, and 1 / 4 c.logki 2-3 times a day. In / in slowly, with acute myocardial infarct, in a daily dose of 200 mg / kg 4 admission or as a continuous infusions over 48 h, followed by lower doses twice; Patients in chronic gemodialise-2 g once immediately after the conclusion of the next session.

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