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Neoton

See also Phosphocreatine

Roman name

Neoton

The composition and the form of

1 bottle with liofilizirovannam powder for solution for the infusions of fosfokreatina 1 g; in a box 1 or 4 bottle, together with the solvent (water for injection), in bottles of 50 ml and one capelnica or ripped off.

Of drugs

Neoton drug is a synthetic analogue of the intracellular compounds fosfokreatina, which plays an important role in ensuring the energy muscular reductions. In miocarde (heart muscle) and muscle skletna fosfokreatin serves as a carrier of energy and is used for the synthesis of ATP (аденозинтрифосфорно�� acid), which provides energy muscular reductions.

Farmakodinamika

Stops mass sarcolemma ishemizirovannah cardiomyocytes and miotitov, stimulates energy exchange, reduces the size of necrosis and Ischemia. In Ischemia and postishemicescoy reperfuzii has antiaritmicski effect reducing 0-28 activity testing and maintaining physiological function of cells Purkinje fibers.

Indications

Acute myocardial infarction, chronic heart failure, intraoperazionnaya myocardial ischaemia, acute violation of cerebral circulation, prevention of the syndrome of physical strain, improved adaptation to the extreme endurance.

Contraindications

Гиперчувствительност ь.

Side-Effects

The steep declines AD (with the rapid on / in the introduction of amounts in excess of 4 g).

Dosing and Administration

B / 386/1989 In acute myocardial infarct : in the early stages of the symptoms of the type struino 2-4 g, followed by drip infuziei 8-16 grams per 200 ml of water for injection, physiological solution, or 5% glucose solution at the speed of 4 g / h. Over the next five days on a / at 4-8 and the complexity over the duration of therapy and dose drug Uvelicerve.pri chronic heart failure : drip to 3 g drug twice a day for five days, or 2 g of the morning, and 1 g evening drip for 10 Dnei.pri intraoperative myocardial protection : product introduced in the cardioplegicaki solution of 3 g / O Neoton added to the solution directly to the introduction. That the course infusions to 2 g twice a day for three to five days prior to surgery, and within 1-2 days after Operation.pri opportunities for the development of intraoperative Cerebral limbs : struino encouraged to 2-4 g preparation before the operation and then infuziei 8-10 g during operation and reperfuzii period. The thesis, ailments, trauma and toxic liver CNS has long continuous cefuroxim drug in the dose of 120 mg / kg / sut.

Storage conditions

por.liof.d / inf. : List B. At temperatures below 30 ° C

Shelf life

por.liof.d / inf. : 3 and

Indications for use

Correction of metabolic defects in rats; Miocardioskleros (excess of connective tissue in the heart). (See also p. 168).

Form of

Neoton 500 : Chest 6 flakonami neotona 500 mg and 6 ampoules to 4 ml solvent; Neoton 1 g flebo : box containing one bottle with 1 g neoton, one bottle from 50 ml of the solvent and a transfusion fluid; Neoton 1 g flebo : box contains four canisters with 1 g neotona.

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