Phosphocreatine

Chemical name

N-[Имино(фосфонамино)м��тил]-N-метилглицин (and in the form of disodium salt)

Gross

C4-H10-N3-O5-P

Of drugs

The drugs-cardioproteguoe, membranes, antiaritmicescoe, metabolicescoe. Improves cardiac metabolism, vnutricletocny transport of energy down mass sarcolemma ishemizirovannah cardiomyocytes. It stimulates microcirculation, reduces size and stood in the way of expansion of the zone of necrosis and Ischemia. With Cerebral and postishemicescoy reperfuzii is antiaritmicski effects : 0-28 suppresses ventricular activity without disrupting the continuity of style in Purkine.pri / Infusion in C_max created 2-3-i mines. Passes gistogematicalkie barriers and accumulates in miocarde, brain, skeletal muscular. Eliminations dwuhfaznoe : T_1/2 rapid phase-20-30 minutes, slow for a few hours. Excreted in the urine.

Indications

Acute myocardial infarction, chronic heart failure, intraoperazionnaya myocardial ischaemia, acute violation of cerebral circulation, prevention of the syndrome of physical strain, improved adaptation to the extreme endurance.

Contraindications

Гиперчувствительност ь.

Side-Effects

Acute gipotenzia (with the rapid on / in the introduction of amounts in excess of 4 g).

Patient interaction

Increases efficiency complications, and antianginalnah drastic drugs.

Dosing and Administration

V / m at 0.5-1 g / d; In / in for 1-2 g / sut. In acute myocardial Ischemia : in the first day, in / in bolusno 2 g, followed by drip infuziei 4 g / hr for 2 hours; Th days of 4-8 grams daily. The residents added (10 mmol / l) in cardioplegicakie solutions.

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