Aprotinin

Chemical name

Odnotsepochechny polypeptide containing 58 amino acids.

Gross

C284-H432-N84-O79-S7

Characteristics

Antifermentny product obtained from the (light, etc.) cattle polivalennetary inhibitor Proteinaz.aguosti Aprotinin expressed in different units : CIE - kallickrein inaguirute unit; Ph.Eur.U-trypsin inaguirute units European Pharmacopoeia, 1 Ph.Eur.U the CIE 1800; Atre - antitripsinove units 1 Atre the CIE 1.33; U units of the enzyme on the State Farmakopee USSR.

Of drugs

The drugs-antifibrinoliticescoe, gemostaticescoe, антипротеолитическое . Ingibiruet proteoliticaskie enzymes (trypsin, himotripsin, kallickrein, plazmin, etc.) in the blood and tissues. After the on / in the rapidly distributed in vnecleternm space, briefly stored in the liver. T_1/2 from blood plasma-150 min. Slowly disintegrated under the lysosomal enzymes kidneys and excreted in urine. Antiproteaznaya activity determines the efficiency losses in the pancreas and other places with high kallickreina and other proteinaz plasma and tissues. Ingibiruya plazmin lowering activity fibrinoliticescuu blood down fibrinoliz and provides gemostaticescoe up at koagulopatiah. The blockade kallickrein-kininova system allows the use of aprotinin for the prevention and treatment of various forms of shock, and angioneuroticescom oteke.

Indications

Pancreatitis (acute, and the exacerbation of a chronic illness, the prevention of postoperative), pankreonekros, гиперфибринолитическ ие bleeding-post, post (especially from the operations in the prostate gland, lung), before, during and after childbirth, complications tromboliticescoy therapy operations in the open-heart with the use of artificial aids circulation, etc., treatment and prevention of various forms of shock (endotoksicski trauma, haemolytic), posleoperazionny parotitis.

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy (in II and III trimestrah unless it is absolutely necessary). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, putting syndrome, pregnancy (I term), breast-feeding.

Side-Effects

From the nervous system and sensory organs : hallucinations, sputannosti consciousness Psihozy.so the circulatory system and blood (blood, gemostaz) : arterial gipotenzia, Tahikardia.prochie : bronhospazm, allergic (skin rash) and anaphylacticskie (up to anaphylacticski shock) reaction; With the rapid introduction, nausea, vomiting; In a long-throm at injections.

Specific guidance

Comparison spent objective methods (the number of Aprotinin at VJH and trypsin activity), it follows that one amp. 15 U ingitrila is 1 amp. 10,000 contrikala Atre.

Patient interaction

Farmatsevticeski incompatible with the other property (except solutions electrolytes and glucose). Reduced activity fibrinoliticakih funds, including streptokinaza, urokinaza.

Precautions

In / in the set only in the rest. The application must be skin test to detect possible individual гиперчувствительност и. The caution should appoint persons prone to allergic reactions, as well as patients with two or three days to receive muscle relaxants. In developing anaphylacticakih reactions a cease immediately and hold the therapy.

Dosing and Administration

B / in (slow) struino or drip. Dose picked individually, depending on the state Ballogo.pri pankreatite : Acute pankreatite - 300000-1000000 CIE / day for 2-6 days, the worsening of chronic-25000-50000 CIE / day for 3-6 days, for the prevention of traumatic pancreatitis - CIE 200,000 to the operation and 100,000 CIE every 6 h after Vmeshatelstwa.pri гиперфибринолитическ их koagulopatiah give high doses (1 million CIE and above). When violations hemostasis in children appointed dose 20,000 CIE / kg / Sut.pri long minor artistic methods to the local applications dose CIE 100,000 in the form of saturated solution Salfetok.pri drug discovery : in the initial dose 300000-400000 CIE, followed by 200,000 in CIE / struino in every 4 hours

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