Hyaluronidase

Characteristics

Liofilizirovanny powder or porous mass bright colors with Judean nuance, is highly soluble in water.

Of drugs

The drugs-proteoliticescoe. Decreases viscosity hyaluronic acid, is the disruption of the relationship between S_1 azetilglukozamina and S_4 glukuronova acid. Increases tissue permeability, improves their trofiku increases elasticity rubtsovoizmenennah sites to myorelaxation bruises and resolve contractures, increases joint mobility. Facilitated diffusion in the liquid meztkanevom space ( "the spread") : the rate of diffusion proportional to the amount of enzyme, and the zone-volume solution. When in / to the application (0,002-20 U / ml), runs until 48 pm And antigenic properties, and re-introductions of large quantities may be produced neutralizing antibodies.

Indications

Contracture of joints, ancylosing spondylitis, sklerodermia traumatic defeat plexus and peripheral nerves (pleksit, involuntary), bruises, severe disease in the lumbar discs, myocardial infarction, hydrocephaly, for the improvement of gas injectable s / c or / m solutions radiocontrastnykh substances local anaesthetics keratitis (for a thinner rubtsevania the affected eye); Scars from burns and operations, long-term psychological and nutritional radiation ulcer; Integrated therapy of asthma, allergic rinita, Arachnoiditis, pulmonary tuberculosis, complicated nonspecific bronchial lesion, rheumatoid arthritis.

Contraindications

Hypersensitivity, acute inflammatory and infectious diseases, malignant neoplasms, lung haemorrhage and krovoharkanye, tuberculosis light with respiratory distress, fresh blood in steklovidne body.

Side-Effects

Allergic reactions (including anaphylactoidnye) fibrillace VLP (very rarely); In the injection-pain and infiltrata.

Specific guidance

Solutions for injection producing izotonicescom solution of sodium chloride or 0.5% novokaine; Inhalations for at izotonicescom solution of sodium chloride; Electrophoresis in distilled water.

Patient interaction

Improves skin medications imposed p / to or / m accelerates pain in the imposition of local anaesthetics.

Overdosing

Symptoms : fever, nausea, vomiting, dizziness, tachycardia and gipotenzia, local swelling, urticaria, Eritema.lechenie : introduction sports, glucocorticoids; Antipruritic drugs.

Precautions

Before applying the necessary test sensitivity gialuronidze (0.02 ml / k). There should be a zone of infection, acute inflammation, tumors; Carefully appointed in combination with other drugs (neprognoziruemoe adsorption acceleration and the increase in the system). Not recommended combined with estrogenami. When pregnancy and breastfeeding is only used in cases of extreme necessity.

Dosing and Administration

P / for the (near destruction or rubtsovoizmenenne fabrics), in / m or inhalation 64 U daily or every other day. Exchange-20 injections or 20-25 Ingalyatsi.metodom electrophoresis for 20-30 minutes (10-15 sessions). In ophthalmology for instillation in the eyes of a 0.1% solution (at the same time using antibacterial products), can be injected retrobulbarno under haemorrhage and under the skin temple.

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