Isodibut

Chemical name

1,3-Диоксо-1H-бенз[d,e]изо��инолин-2(3H)масляная acid

Of drugs

The drugs-neiroproteguoe, angioproteguoe, improves tissue metabolism. Ingibiruet aldozoredouktazu is a key enzyme zitoplazmaticeski sorbitnogo ways and violates nefosfaurilirovanna conversion of glucose in sorbit. Prevent the accumulation of cells within the end-products of glucose on the sorbitnomu (fruit-sugar and sorbit) are badly penetrate via cell membrane, and the development of cellular giperosmolarnosti; Warns penetration of liquid in the cell schwannovskie peripheral nerves, degeneration, segmentarnuu demielinizatiou or aksonopatiu. Prevents accumulation of electricity in other tissues, including in aorte, hrustalike. Has accumulation никотинамидадениндин уклеотидфосфата and the Advancement of glutathione (one of the most important antioxidants, reducing the number of free radicals generated in abundance in oksidativom stress). Increases activity No-sintaza in endotelialnah cells and stimulates the synthesis of nitric oxide (NO), a neironalnam messengerom in the CNS, endotelialnam Bath factor in improving the blood supply to the tissues. Partly reduces release of serotonin and GABA from sinaptosom. Normalizes the Na ^ + K ^ + -atfaza and level of electricity in the brain and peripheral nerves. Decreases pronounced brain and slows development of the circulation system.

Indications

Neiropatia diabetic, angiopatia, retinopathy; Cataracts, Menkeberg Disease.

Contraindications

Hypersensitivity, severe liver disease, kidney and stomach.

Side-Effects

Skin allergies.

Precautions

In the human digestive tract to appoint after eating.

Dosing and Administration

Inside, before delivery, to 0.5 g 3-4 times per day; Maximum daily intake - 4 and Duration - 3m. Again course six months.

Literature

Chistyagov DA, Turakulov RI, Gorasko NM and others. Study polymorphism dinukleotidnyi repeat within a gene aldozoreduktaza rates among patients insulin-zawisimam diabetics with circulatory осложнениями//Молекул яр. Biology-1997 .- T. 31 N-5 .- S. 778-783.

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