Traskolan

Roman name

Traskolan #

The composition and the form of

1 ml solution for injection contains Aprotinin 5,000 or 10,000 CIE; 182,000,000 in 10 ml, in a package 5 pcs.

Of drugs

Gemostaticescoe, antiproteaznoe. Links proteoliticaskie enzymes (trypsin, himotripsin, kallickrein), including : trigger fibrinoliz (plazmin).

Farmakodinamika

Inactivate proteinase plasma (plazmin, kininogenaza, trypsin, himotripsin), blood cells and tissues. Antiproteaznaya activity determines the effectiveness of the acute pankreatite. Ingibiruya plazmin lowering activity fibrinoliticescuu blood down fibrinoliz and provides gemostaticescoe up at koagulopatiah. The blockade kallickrein-kininova system allows for the prevention and treatment of various forms of shock (endotoksicski, traumatic, haemolytic).

Indications

Acute pancreatitis, peritonitis, гиперфибринолитическ ие bleeding, bloody trauma and toxic shock fat embolism, postoperative bleeding, posleoperazionny pancreatitis.

Contraindications

Гиперчувствительност ь.

Side-Effects

Erythema, urticaria, bronhospazm, nausea, vomiting, mialgia, lability AD rarely hallucinations, sputannosti consciousness psychosis.

Patient interaction

Incompatible with korticosteroidami, as well as infusion solutions containing amino acids and fat emulsion.

Precautions

The application must be skin test to detect possible гиперчувствительност и. To apply caution in patients who have two or three days before the appointment muscle.

Dosing and Administration

In / in struino or drip. Dose picked individually, depending on the condition of the patient. Acute pancreatitis : 500000-1000000 CIE without dilution, at speeds of up to 5 ml / min, and then on the 500k CIE daily drip. The improvement in the general patient dose gradually reduced. The treatment (if necessary) to up to 15 Dnei.tagelae state : after the bolusni encouraged to continue treatment drip Quick 100,000 CIE / h for a period of 8 to 12 hours before the clinical улучшения.Фибринолит��ческие bleeding : drip, in the dose 100000-200000 CIE, as necessary, to 500,000 CIE, depending on the intensity of Krovotechenia.s objective in surgery : 200000-400000 CIE operation before, during and after it, and then on the CIE 100,000 in the next two days.

Storage conditions

r-r d / in. : List B. The temperature is not above 15 ° C

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